Hepatitis C Virus Treatment

Highly Effective Therapy with Direct Acting Antivirals and Associated Viral Resistance

Editors: Chayama, Kazuaki (Ed.)

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  • Introduces new therapies available for treating chronic hepatitis C
  • Describes Direct Acting Antiviral Agents (DAA), which have an excellent anti-viral effect on virus replication
  • Provides cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-981-10-2416-0
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-981-10-2415-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-981-10-9610-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication. These drugs have been developed to enhance the effect of interferon and ribavirin, as the resistant strains against each drug have been described both in vitro and in vivo and the existences of naturally occurring variants have been reported. However, since the combination of different classes of DAAs is sufficient to completely eradicate the virus without the need for interferon or ribavirin, the current treatment regimen does not include interferon. Ribavirin is used in combination with sofosbuvir, a potent polymerase inhibitor, to enhance its antiviral effects.

Hepatitis C Virus Treatment offers readers a comprehensive guide to hepatitis C; describing the resistance profiles against these drugs and shedding light on the difficulties involved in DAA therapy and the direction of future treatments, it will equip doctors to understand the essentials of treating the disease. It also describes in detail new and innovative DAA treatments, the effects of the agents, and the characteristics of resistance, providing cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students.

About the authors

Prof. Kazuaki ChayamaDepartment of Gastroenterology and Metabolism, Applied Life Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Treatment of Chronic Hepatitis C with the First-Generation Protease Inhibitor Telaprevir: Its Efficacy and Resistance Mutations

    Karino, Yoshiyasu

    Pages 1-8

  • Features of the Second Wave of the First Generation Protease Inhibitors: Effect and Tolerance

    Takehara, Tetsuo

    Pages 9-16

  • The Efficacy of Daclatasvir Plus Asunaprevir Combination Therapy with Chronic Hepatitis

    Mitsui, Fukiko (et al.)

    Pages 17-24

  • Resistance-Associated Variants in the NS5A Region of HCV and Methods for the Detection

    Mochida, Satoshi, MD, PhD

    Pages 25-32

  • Detection of Antiviral Drug-Resistant Variants in Chronic Hepatitis C by Deep Sequencing

    Maekawa, Shinya (et al.)

    Pages 33-43

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-981-10-2416-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-981-10-2415-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-981-10-9610-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Hepatitis C Virus Treatment
Book Subtitle
Highly Effective Therapy with Direct Acting Antivirals and Associated Viral Resistance
Editors
  • Kazuaki Chayama
Copyright
2017
Publisher
Springer Singapore
Copyright Holder
Springer Science+Business Media Singapore
eBook ISBN
978-981-10-2416-0
DOI
10.1007/978-981-10-2416-0
Hardcover ISBN
978-981-10-2415-3
Softcover ISBN
978-981-10-9610-5
Edition Number
1
Number of Pages
VII, 75
Number of Illustrations
9 b/w illustrations, 14 illustrations in colour
Topics