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Frontiers of Biostatistical Methods and Applications in Clinical Oncology

Editors: Matsui, Shigeyuki, Crowley, John (Eds.)

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  • Presents the state of the art of biostatistics in clinical oncology, covering various topics from design and analysis of modern clinical trials, disease screening, prognostic analysis, and analysis of large-scale molecular data
  • Is written by experts in biostatistical methodology and practice in cancer clinical studies
  • Sets forth an effective balance between biostatistical methodology and practice
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eBook $109.00
price for USA in USD
  • ISBN 978-981-10-0126-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
Softcover $139.99
price for USA in USD
About this book

This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.

About the authors

Shigeyuki Matsui, Professor, Department of Biostatistics, Nagoya University Graduate School of Medicine, smatsui@med.nagoya-u.ac.jp, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
John Crowley, President and CEO, Cancer Research and Biostatistics, johnc@crab.org, 1730 Minor Ave STE 1900  Seattle, WA 98101-1468

Reviews

“I strongly recommend that those statisticians working in the clinical oncology field check out these articles. Several were of use to me and I know that others will find them to be of use as well.” (David E. Booth, Technometrics, Vol. 60 (3), 2018) ​

Table of contents (25 chapters)

Table of contents (25 chapters)
  • Challenges for Biometry in 21st Century Oncology

    Pages 1-9

    Simon, Richard

  • Statistical Challenges with the Advances in Cancer Therapies

    Pages 11-20

    Sridhara, Rajeshwari

  • Random Walk and Parallel Crossing Bayesian Optimal Interval Design for Dose Finding with Combined Drugs

    Pages 21-35

    Lin, Ruitao (et al.)

  • A Comparative Study of Model-Based Dose-Finding Methods for Two-Agent Combination Trials

    Pages 37-52

    Hirakawa, Akihiro (et al.)

  • Evaluation of Safety in Biomarker Driven Multiple Agent Phase IB Trial

    Pages 53-64

    Mori, Motomi (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-981-10-0126-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
Softcover $139.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Frontiers of Biostatistical Methods and Applications in Clinical Oncology
Editors
  • Shigeyuki Matsui
  • John Crowley
Copyright
2017
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-0126-0
DOI
10.1007/978-981-10-0126-0
Hardcover ISBN
978-981-10-0124-6
Softcover ISBN
978-981-10-9086-8
Edition Number
1
Number of Pages
XIII, 438
Number of Illustrations
89 b/w illustrations
Topics