Translational Bioinformatics

Computational and Statistical Epigenomics

Editors: Teschendorff, Andrew E. (Ed.)

  • Introduces computational and statistical tools needed for a successful translation from bench to bedside  
  • A special focus on DNA methylation data  
  • Covers the application of these tools
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-94-017-9927-0
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-94-017-9926-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.99
price for USA in USD
  • ISBN 978-94-024-0343-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book introduces the reader to modern computational and statistical tools for translational epigenomics research. Over the last decade, epigenomics has emerged as a key area of molecular biology, epidemiology and genome medicine. Epigenomics not only offers us a deeper understanding of fundamental cellular biology, but also provides us with the basis for an improved understanding and management of complex diseases. From novel biomarkers for risk prediction, early detection, diagnosis and prognosis of common diseases, to novel therapeutic strategies, epigenomics is set to play a key role in the personalized medicine of the future. In this book we introduce the reader to some of the most important computational and statistical methods for analyzing epigenomic data, with a special focus on DNA methylation. Topics include normalization, correction for cellular heterogeneity, batch effects, clustering, supervised analysis and integrative methods for systems epigenomics. This book will be of interest to students and researchers in bioinformatics, biostatistics, biologists and clinicians alike.

Dr. Andrew E. Teschendorff is Head of the Computational Systems Genomics Lab at the CAS-MPG Partner Institute for Computational Biology, Shanghai, China, as well as an Honorary Research Fellow at the UCL Cancer Institute, University College London, UK.

Reviews

“This volume in the Translational Bioinformatics series introduces modern computational and statistical tools for translational epigenomic research with a special focus on DNA methylation. … This is a valuable resource for students, clinicians, and researchers who wish to understand the basics of modern computational and statistical tools for translational epigenomics research. The analytical, storage-related, and interpretive methods discussed in this book hold great promise in helping improve prediction, early diagnosis, severity monitoring, therapeutic effect, and prognosis of human diseases.” (Pooja Sethi, Doody’s Book Reviews, July, 2015)


Table of contents (9 chapters)

  • Introduction to Data Types in Epigenomics

    Marabita, Francesco (et al.)

    Pages 3-34

  • DNA Methylation and Cell-Type Distribution

    Houseman, E. Andrés

    Pages 35-50

  • A General Strategy for Inter-sample Variability Assessment and Normalisation

    Yang, Zhen (et al.)

    Pages 51-68

  • Quantitative Comparison of ChIP-Seq Data Sets Using MAnorm

    Shao, Zhen (et al.)

    Pages 69-90

  • Model-Based Clustering of DNA Methylation Array Data

    Koestler, Devin C. (et al.)

    Pages 91-123

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-94-017-9927-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-94-017-9926-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.99
price for USA in USD
  • ISBN 978-94-024-0343-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Computational and Statistical Epigenomics
Editors
  • Andrew E. Teschendorff
Series Title
Translational Bioinformatics
Series Volume
7
Copyright
2015
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-9927-0
DOI
10.1007/978-94-017-9927-0
Hardcover ISBN
978-94-017-9926-3
Softcover ISBN
978-94-024-0343-5
Series ISSN
2213-2775
Edition Number
1
Number of Pages
V, 217
Number of Illustrations and Tables
1 b/w illustrations, 41 illustrations in colour
Topics