Multifaceted Roles of Crystallography in Modern Drug Discovery
Editors: Scapin, Giovanna, Patel, Disha, Arnold, Eddy (Eds.)
Free Preview- Covering a variety of complementary experimental technologies
- Providing an up-to-date overview of structure based drug discovery and development
- Describing macromolecule-centred and ligand-centred techniques
- Presenting topics of interest to a wide audience, including structural biologists, computational chemists, and medicinal chemists
Buy this book
- About this book
-
The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design.
- Table of contents (17 chapters)
-
-
Engineering G Protein-Coupled Receptors for Drug Design
Pages 1-18
-
Structural Insights into Activation and Allosteric Modulation of G Protein-Coupled Receptors
Pages 19-26
-
Epigenetic Drug Discovery
Pages 27-40
-
Crystallography and Biopharmaceuticals
Pages 41-52
-
Structural Chemistry and Molecular Modeling in the Design of DPP4 Inhibitors
Pages 53-67
-
Table of contents (17 chapters)
- Download Preface 1 PDF (26.7 KB)
- Download Sample pages 2 PDF (398.5 KB)
- Download Table of contents PDF (24 KB)
Recommended for you
Bibliographic Information
- Bibliographic Information
-
- Book Title
- Multifaceted Roles of Crystallography in Modern Drug Discovery
- Editors
-
- Giovanna Scapin
- Disha Patel
- Eddy Arnold
- Series Title
- NATO Science for Peace and Security Series A: Chemistry and Biology
- Copyright
- 2015
- Publisher
- Springer Netherlands
- Copyright Holder
- Springer Science+Business Media Dordrecht
- eBook ISBN
- 978-94-017-9719-1
- DOI
- 10.1007/978-94-017-9719-1
- Hardcover ISBN
- 978-94-017-9718-4
- Softcover ISBN
- 978-94-017-9724-5
- Series ISSN
- 1874-6489
- Edition Number
- 1
- Number of Pages
- XI, 240
- Number of Illustrations
- 18 b/w illustrations, 89 illustrations in colour
- Topics
