NATO Science for Peace and Security Series A: Chemistry and Biology

Multifaceted Roles of Crystallography in Modern Drug Discovery

Editors: Scapin, Giovanna, Patel, Disha, Arnold, Eddy (Eds.)

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  • Covering a variety of complementary experimental technologies
  • Providing an up-to-date overview of structure based drug discovery and development
  • Describing macromolecule-centred and ligand-centred techniques
  • Presenting topics of interest to a wide audience, including structural biologists, computational chemists, and medicinal chemists
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eBook $69.99
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  • ISBN 978-94-017-9719-1
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Hardcover $189.00
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  • ISBN 978-94-017-9718-4
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Softcover $89.99
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  • ISBN 978-94-017-9724-5
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About this book

The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design.

Table of contents (17 chapters)

Table of contents (17 chapters)

Buy this book

eBook $69.99
price for USA in USD
  • ISBN 978-94-017-9719-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA in USD
  • ISBN 978-94-017-9718-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $89.99
price for USA in USD
  • ISBN 978-94-017-9724-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Multifaceted Roles of Crystallography in Modern Drug Discovery
Editors
  • Giovanna Scapin
  • Disha Patel
  • Eddy Arnold
Series Title
NATO Science for Peace and Security Series A: Chemistry and Biology
Copyright
2015
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-9719-1
DOI
10.1007/978-94-017-9719-1
Hardcover ISBN
978-94-017-9718-4
Softcover ISBN
978-94-017-9724-5
Series ISSN
1874-6489
Edition Number
1
Number of Pages
XI, 240
Number of Illustrations
18 b/w illustrations, 89 illustrations in colour
Topics