Subcellular Biochemistry

MACPF/CDC Proteins - Agents of Defence, Attack and Invasion

Editors: Anderluh, Gregor, Gilbert, Robert (Eds.)

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  • A comprehensive overview of one of the largest pore forming proteins superfamilies
  • A special chapter on methodology allowing the study of mechanisms of pore formation
  • Several novel data reviews which provide new insights into the distribution of MACPF/CDC proteins throughout biology
  • In depth perspectives on MACPF/CDCs from multiple fields of study: medicine, biology, biophysics, applications-based, technical development
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eBook $169.00
price for USA in USD
  • ISBN 978-94-017-8881-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
Softcover $219.99
price for USA in USD
About this book

This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.

The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Introduction: Brief Historical Overview

    Pages 3-6

    Goot, Gisou F.

  • Distribution of MACPF/CDC Proteins

    Pages 7-30

    Anderluh, Gregor (et al.)

  • Evolution of the Complement System

    Pages 31-43

    Nonaka, Masaru

  • Structural Features of Cholesterol Dependent Cytolysins and Comparison to Other MACPF-Domain Containing Proteins

    Pages 47-62

    Gilbert, Robert

  • Perfringolysin O Structure and Mechanism of Pore Formation as a Paradigm for Cholesterol-Dependent Cytolysins

    Pages 63-81

    Johnson, Benjamin B. (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-94-017-8881-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
Softcover $219.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
MACPF/CDC Proteins - Agents of Defence, Attack and Invasion
Editors
  • Gregor Anderluh
  • Robert Gilbert
Series Title
Subcellular Biochemistry
Series Volume
80
Copyright
2014
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-8881-6
DOI
10.1007/978-94-017-8881-6
Hardcover ISBN
978-94-017-8880-9
Softcover ISBN
978-94-024-0339-8
Series ISSN
0306-0225
Edition Number
1
Number of Pages
XI, 329
Number of Illustrations
5 b/w illustrations, 52 illustrations in colour
Topics