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Progress in Hormone Biochemistry

Progress in Hormone Biochemistry and Pharmacology

Authors: Briggs, M., Corbin, A.

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About this book

Somatostatin was discovered in 1971, by Guillemin and his colleagues during their search for the hypothalamic growth hormone-releasing factor. A peptide was found in ovine hypothalamus which inhibited the release of growth hormone from cultured anterior pituitary cells. 1,2 Determination 3 of its amino acid sequence indicated that it was a tetradecapeptide with a molecular weight of 1639 (Figure lJ. An identical peptide was later isolated from porcine hypothalamus by Schally and his coworkers. 4 The peptide was named somatostatin in the belief that it was a hypothalamic releasing factor whose sole function was to inhibit the secretion of growth hormone. It soon became evident, however, that a peptide with identical immunologic characteristics and biologic activity was present in the D cells of pancreatic islets, in D-like cells of the gastrointestinal tract, in parafollicular cells of the thyroid gland, and in extrahypo­ thalamic neurons of both the central and peripheral nervous system in various species, including man. Moreover, studies employing synthetic somatostatin5 demonstrated that the peptide possessed a wide spectrum of biologic activities in addition to its inhibition of growth hormone. 56 S 0 MAT 0 S TAT I N 6 1 2 3 4 5 7 Ala-Gly-Cys-Lys-Asn-Phe-Phe I I S Trp 8 ~ L~S 9 I I Cys-Ser-Thr-Phe-Thr 14 13 12 11 10 FIG. 1: Structure of somatostatin 57 II. GENERAL DISTRIBUTION AND ACTIONS Somatostatin is widely distributed within both the central and peripheral nervous systems and in various other tissues (Table 1).

Table of contents (4 chapters)

Table of contents (4 chapters)
  • The Renin-Angiotensin System, Converting Enzyme Inhibition, and Antihypertensive Therapy

    Pages 1-53

    Rubin, B. (et al.)

  • The Pharmacology and Potential Clinical Applications of Somatostatin and its Analogues

    Pages 55-147

    Gerich, J. E.

  • Botanical Sources of Fertility Regulating Agents: Chemistry and Pharmacology

    Pages 149-225

    Bingel, A. S. (et al.)

  • Luteinizing Hormone Releasing Hormone and Analogues: Conceptive and Contraceptive Potential

    Pages 227-297

    Corbin, A. (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-94-011-7712-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.99
price for USA in USD
  • ISBN 978-94-011-7714-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Progress in Hormone Biochemistry and Pharmacology
Authors
Series Title
Progress in Hormone Biochemistry
Series Volume
1
Copyright
1980
Publisher
Springer Netherlands
Copyright Holder
Eden Press Incorporated
eBook ISBN
978-94-011-7712-2
DOI
10.1007/978-94-011-7712-2
Softcover ISBN
978-94-011-7714-6
Edition Number
1
Number of Pages
X, 302
Number of Illustrations
8 b/w illustrations
Topics