Advances in the Study of Birth Defects

Teratological Testing

Editors: Persaud, T.V.N. (Ed.)

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About this book

The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mec.;hanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The· contributions in this volume deal primarily with the areas of terato­ logical evaluation and the use of selected animal models for the study of con­ genital anomalies. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.

Table of contents (17 chapters)

Table of contents (17 chapters)
  • Primate teratology: selection of species and future use

    Pages 1-23

    Hendrickx, A. G. (et al.)

  • Usefulness of Golden Syrian hamster in experimental teratology with particular reference to the induction of orofacial malformations

    Pages 25-39

    Shah, R. M.

  • Morphogenetic systems and the central phenomena of teratology

    Pages 41-67

    Jelínek, R. (et al.)

  • Some problems of chemical teratogenesis

    Pages 69-94

    Sandor, S. (et al.)

  • Cyclophosphamide treatment prior to implantation: the effects on embryonic development

    Pages 95-112

    Spielmann, H. (et al.)

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-94-011-6651-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-94-011-6653-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Teratological Testing
Editors
  • T.V.N. Persaud
Series Title
Advances in the Study of Birth Defects
Series Volume
2
Copyright
1979
Publisher
Springer Netherlands
Copyright Holder
MTP Press Limited
eBook ISBN
978-94-011-6651-5
DOI
10.1007/978-94-011-6651-5
Softcover ISBN
978-94-011-6653-9
Edition Number
1
Number of Pages
357
Topics