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Developments in Oncology

Minimal Residual Disease in Acute Leukemia

Editors: Löwenberg, B., Hagenbeek, A. (Eds.)

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About this book

The objective of the treatment of acute leukemia involves the eradication of all neoplastic cells, including the last one. Ideally, treatment should be controlled by monitoring cell kill. If the last cells could be discovered and their biological properties be determined, the qualitative and quantitative effects of treatment should be directly evaluable. This should ultimately permit a calculated tumor cell reduction thereby avoiding overtreatment and excessive toxicity and thus providing a basis for individualized antileukemic treatment. In recent years several new developments have contributed to the selective discovery of minimal numbers of leukemic cells which are hidden among the normal cells in the marrow cavities. These methods are the first steps to the realization of the therapeutic goals indicated above. They include the production and ap­ plication of monoclonal antibodies against differentiation antigens on the cell sur­ face, the use of pulse cytophotometry - and cell sorter techniques, the employment of cytogenetics, the development of culture techniques for selective growth of precursor cells and several others. These methodologies offer prospects for refined diagnosis and, as far as the elimination of leukemic cells is concerned, the further development of autologous bone marrow transplantation. Eliminating tumor cells from autologous grafts requires the detailed knowledge of the cellular inter­ relationships within the neoplasm so that the neoplastic cells responsible for tumor propagation are specifically removed. Recognition and characterization of the clonogenic cells of the neoplasm should then lead to determining their sensitivity to the therapeutic agents which are clinically applied.

Table of contents (31 chapters)

Table of contents (31 chapters)
  • Nucleic Acid Cytometry, Interphase Chromosomes and Nucleolar Antigen in the Detection of Residual Leukemia in Morphologic Remission

    Pages 1-18

    Barlogie, B. (et al.)

  • Automated Detection of Rare Hemopoietic Cell Types by Flow Cytometry and Image Analysis

    Pages 19-43

    Visser, J. W. M.

  • Detection of Minimal Residual Leukemia Utilizing Monoclonal Antibodies and Fluorescence Activated Cell Sorting (FACS)

    Pages 45-54

    Hagenbeek, Anton (et al.)

  • Discrimination Between Normal Hemopoietic Stem Cells and Myeloid Leukemia Cells Using Monoclonal Antibodies

    Pages 55-65

    Lange, Beverly (et al.)

  • Detection of Minimal Residual Disease in TdT Positive T Cell Malignancies by Double Immunofluorescence Staining

    Pages 67-81

    Dongen, J. J. M. (et al.)

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-94-009-5670-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.99
price for USA in USD
  • ISBN 978-94-010-9002-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Minimal Residual Disease in Acute Leukemia
Editors
  • B. Löwenberg
  • A. Hagenbeek
Series Title
Developments in Oncology
Series Volume
19
Copyright
1984
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-009-5670-4
DOI
10.1007/978-94-009-5670-4
Softcover ISBN
978-94-010-9002-5
Edition Number
1
Number of Pages
416
Number of Illustrations
17 b/w illustrations
Topics