Brain Oncology Biology, diagnosis and therapy

1. Front Matter

   Pages I-XIX

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2. Oncogenesis

   1. Front Matter

      Pages 1-1

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   2. Genetics Of Neuroepithelial Brain Tumours

      • C. C. Tijssen

      Pages 3-6

   3. Oncogenes, Growth Factors and the Pathogenesis of Human Glioma: The 1986 Engelhardt Lecture

      • B. Westermark, M. Nistér, C. H. Heldin

      Pages 7-13

   4. Amplification and Expression of Viral Sequences and Oncogenes in Human Brain Tumors

      • A. L. Benabid, C. Chauvin, A. M. Foote, M. Suh, M. Danik, M. Laine et al.

      Pages 15-19

   5. Chromosomal Studies in Malignant Gliomas

      • S. H. Bigner

      Pages 21-23

   6. Karyotype Patterns in Forty Human Meningiomas

      • P. Simi, E. Tarantino, D. Parrini, M.-C. Cagno, R. Buonaguidi

      Pages 25-28

3. Neuropathology

   1. Front Matter

      Pages 29-29

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   2. Immunohistochemistry in Neuro-Oncology: Markers or Signposts?

      • L. J. Rubinstein

      Pages 31-34

   3. Immunocytochemistry and the Pathological Diagnosis of Cerebral Tumours

      • R. O. Weller

      Pages 35-39

   4. GFAP Immunoreactivity of Oligoastrocytomas Study of 120 Cases

      • J. R. Iglesias, E. Kazner, C. Aruffo

      Pages 41-45

   5. GFA and S 100 Proteins in Low Grade Astrocytomas

      • B. Lechevalier, F. Chapon, J. F. Viel, J. P. Houtteville

      Pages 47-53

   6. Intermediate Filaments in Fresh Frozen Tissue in Neuro-Oncology — About a Series of 1000 Peroperative Biopsies —

      • Y. Krivosic, M. Jomin, J. L. Christiaens, P. Dhellemmes, G. Combelles, F. Lesoin et al.

      Pages 55-60

   7. Glutamine Synthetase, a Marker of an Astroglial Subpopulation in Mouse Brain

      • M. Tardy, C. Fages, M. Kheli, B. Rolland

      Pages 61-65

   8. Correlation of in situ cell Kinetics and Degree of Anaplasia in Human Brain Tumors: Identification of S-phase cells with anti-BUdR Antibodies

      • S. J. De Armond, T. Nagashima, K. G. Cho, J. A. Murovic, R. L. Davis, T. Hoshino

      Pages 67-74

   9. Prognostic Value of Labeling Index in Stereotactic Biopsies of Glial Tumours

      • G. Broggi, A. Franzini, S. Ferraresi, C. Giorgi, A. Allegranza

      Pages 75-78

   10. Proliferative Potential of Malignant and Non-Malignant Meningiomas

       • K. G. Cho, T. Hoshino, T. Nagashima, R. L. Davis

       Pages 79-81

   11. Histological Patterns in Germ Cell Tumors

       • J. Verlooy, P. Cras, P. Selosse, J. J. Martin

       Pages 83-85

   12. Dysontogenetic Brain Tumours. Morphological Variability and Problems of Classification

       • G. F. Walter

       Pages 87-90

   13. Congenital intracranial tumors

       • J. Bohl, H. H. Goebel, S. Al-Hami, D. Voth, P. Gutjahr

       Pages 91-99

The International Meeting on Brain Oncology in Rennes was organised in honor of Jean Pecker, to pay tribute to his contribution to the development of neurological sciences and to take stock of the current state of knowledge on brain tumors, a domain in which the role of neurosurgery has been and will continue to be primordial. During the two-day conference, the major themes of brain oncology studies, both fundamental and clinical, were examined: oncogenesis, tumoral markers and immunology, metabolic and diagnosis imaging, prognostic factors and therapeutic strategies. The large number and high quality of participations resulted in a genuinely synthetic view of current advances in research, of which this book presents the essentials. We have attempted both to preserve the richness of scientific exchanges which occurred and to publish a great many oral and poster communications. The book respects the organization of conference sessions, and thus reflects the importance accorded to glial tumor studies. This may seem disproportionate given their frequency of occurrence in proportion to total numbers of intracranial tumor processes, but their gravity and quasi-total resistance to current therapeutic methods are ample justification. Moreover, this is the domain in which hopes of progress are beginning to appear, and it is becoming possible to envisage treatment based on recently established fundamental knowledge.

• Grading
• biopsy
• classification
• imaging
• surgery

• Department of Neurology, University of Rennes, France

  M. Chatel

• Department of Neuropathology, University of Rennes, France

  F. Darcel

• Department of Neurosurgery, University of Rennes, France

  J. Pecker

Policies and ethics