Advances in Peptic Ulcer Pathogenesis

Editors: Rees, W.D. (Ed.)

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About this book

Over the past decade a great deal of research activity has occurred on either side of the gastroduodenal epithelial interface, with the common goal of elucidating the mechanisms of mucosal protection and how these may be compromised in peptic ulcer disease. A prime stimulus to such research has been the realization that abnormal acid secretion or its delivery into the duodenum in excessive amount cannot fully explain ulcer pathogenesis in the majority of patients. One may envisage the stomach and proximal duodenum as being in a dynamic equilibrium, with aggressive luminal factors, such as acid and pepsin, being counteracted by protective mucosal mechanisms. Until recently, the mechanisms involved in mucosal protection had been poorly defined while the physiology and pathophysiology of acid and pepsin secretion had been elucidated. The impression that gastroduodenal mucosa was protected by a single mechanism has at last been replaced by a more realistic view, suggesting a number of protective zones acting in series. Some of these zones may act as first or second line defences against aggressive factors while certain zones may specifically protect against certain aggressors.

Table of contents (11 chapters)

Table of contents (11 chapters)

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-94-009-1245-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $79.99
price for USA in USD
  • ISBN 978-94-010-7052-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Advances in Peptic Ulcer Pathogenesis
Editors
  • W.D. Rees
Copyright
1988
Publisher
Springer Netherlands
Copyright Holder
MTP Press Limited
eBook ISBN
978-94-009-1245-8
DOI
10.1007/978-94-009-1245-8
Softcover ISBN
978-94-010-7052-2
Edition Number
1
Number of Pages
250
Topics