Origins and Directions of Inflammatory Bowel Disease

1. Front Matter

   Pages i-ix

   PDF

2. Introduction

   • Joseph B. Kirsner

   Pages 1-11

3. Ulcerative Colitis

   • Joseph B. Kirsner

   Pages 13-54

4. Crohn’s disease

   • Joseph B. Kirsner

   Pages 55-101

5. Etiology and Pathogenesis of IBD — Origins and Directions

   • Joseph B. Kirsner

   Pages 103-204

6. The Early Treatment of Inflammatory Bowel Disease

   • Joseph B. Kirsner

   Pages 207-225

7. Pharmacological Development of Aminosalicylates for the Treatment of Inflammatory Bowel Disease

   • Ulrich Klotz

   Pages 227-234

8. Back Matter

   Pages 237-246

   PDF

Few human illnesses today are so challenging, medically, scientifically, and socio-economically, as the "nonspecific" inflammatory bowel diseases (IBD): ulcerative colitis and Crohn's disease. Originating several centuries ago but essentially diseases of the 20th century, often attacking children and young adults, involving all bodily systems as well as the gastrointestinal tract, ulcerative colitis and Crohn's disease have emerged in recent decades as among the more "glamorous" unsolved diseases, presenting unusual opportunities for insightful clinical and investigative study. Many of the prevailing concepts originated during the early and mid 20th century. The purpose of Origins and Directions of Inflammatory Bowel Disease is to review these earlier studies and their evolution "from the mystical to the molecular," and guide investigators and physicians through the challenging clinical and scientific maze of IBD.

• cell
• children
• cognition
• colon
• cytokine
• diseases
• etiology
• evolution
• gastrointestinal tract
• inflammation
• inflammatory bowel disease
• microscopy
• pathology
• trauma
• treatment

• Department of Medicine, University of Chicago, Chicago, USA

  Joseph B. Kirsner

Policies and ethics