Anaesthesia and Pharmaceutics

1. Front Matter

   Pages I-VIII

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2. Anaesthesia and the Heart

   1. Front Matter

      Pages 1-1

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   2. Alpha and Beta Blockers in Anesthesia

      • H. Laborit

      Pages 3-17

   3. Advantages and Disadvantages of Isoprenaline

      • M. Thomas

      Pages 18-23

   4. Use and Misuse of Oxygen

      • G. Rolly

      Pages 24-29

   5. The Anaesthetic Management of the Surgical Patient with a Cardiac Pacemaker

      • P. J. Janssen

      Pages 30-38

3. Muscle Relaxants

   1. Front Matter

      Pages 39-39

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   2. New Concepts of the Action of Muscle Relaxants

      • S. A. Feldman

      Pages 41-47

   3. The Action of Muscle Relaxants on Cholinergic Mechanisms in the Heart

      • V. A. Goat

      Pages 48-63

   4. Changes of Acid-Base Balance and Muscle Relaxants

      • J. F. Crul, E. J. Crul

      Pages 64-73

   5. The Use of Muscle Relaxants in Anephric Patients

      • D. T. Popescu

      Pages 74-88

4. Effects and Side-Effects of Anaesthetic Agents

   1. Front Matter

      Pages 89-89

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   2. The Truth About Antihypertensive and Anaesthetic Drugs

      • L. Stamenkovic

      Pages 91-103

   3. Drug Interactions in Anaesthesia

      • E. L. Noach

      Pages 104-115

   4. On the Toxicity of Halothane

      • B. R. Simpson, L. Strunin, B. Walton

      Pages 116-129

   5. The Dangers of Anaesthetic Agents to Personnel Working in Operating Theatres

      • Joh. Spierdijk

      Pages 130-139

5. Back Matter

   Pages 141-144

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During the past twenty years there has been a rapid evolution in anaesthesia, so much so, that we stand on the brink of a major change in the role of the anaesthetist in medicine. Anaesthesia has now emerged from being a craft speciality, obsessed with details of techniques, to become a science concerned with the maintenance of life. As a result of our better understanding of the physiological and pharmacological effects of anaesthesia and surgery, new opportunities have been created for anaesthetists to apply their particular knowledge, not only to provide better and safer conditions for surgery, but also in resuscitation, ventilatory and circulatory support and in the treatment of chronic pain. This has resulted in the recognition of the anaesthetist as a physician specialising in applied physiology and clinical pharmacology. The 1971 Boerhaave Course in Anaesthesia has deliberately tried to reflect this scientific basis of the speciality of anaesthesia by selecting for presenta­ tion in this book, subjects in which recent investigations have provoked new concepts and ideas. We are most grateful to our colleagues who presented a paper and to the secretary-staffs of our departments of anaesthesia in Leiden and London. Also thanks are extended to Mrs. Bongertman for the preparation of the proofs. Department of Anaesthesiology 10han Spierdijk University Hospital, Leiden Department of Anaesthetics Stanley Feldman Westminster Hospital, London v CONTENTS Preface . . . V Contributors . VIII PART ONE ANAESTHESIA AND THE HEART Alpha and beta blockers in anaesthesia . 3 H. LABORIT 18 Advantages and disadvantages of isoprenaline .

• anesthesia
• drug
• drugs
• heart
• management
• muscle
• patients
• toxicity

• Department of Anaesthesiology, University Hospital, Leiden, The Netherlands

  Joh. Spierdijk

• Department of Anaesthetics, Westminster Hospital, London, UK

  S. A. Feldman

Policies and ethics