Issues in the Design and Evaluation of Medical Trials

1. Front Matter

   Pages i-ix

   PDF

2. Research and Data

   • John M. Weiner

   Pages 2-16

3. Patient Management and Decision Models

   • John M. Weiner

   Pages 18-36

4. Historical and Current Guidelines for Medical Trials

   • John M. Weiner

   Pages 38-60

5. Research Planning

   • John M. Weiner

   Pages 62-75

6. Information Processing

   • John M. Weiner

   Pages 76-90

7. Analysis of Functions

   • John M. Weiner

   Pages 92-104

8. Allocation and Monitoring

   • John M. Weiner

   Pages 106-120

9. Multi-Institutional and Multi-Disciplinary Research

   • John M. Weiner

   Pages 122-139

10. Back Matter

    Pages 141-206

    PDF

Clinical research represents an integration of many procedures from the social, biological, and natural sciences. Critical examination of the spectrum of medical inquiries will reveal the full gamut of research activities. Under­ standing the processes involved in the integration of these investigative and cognitive functions may lead to further advances in creative behavior. The purpose of this book is to formalize this process by identifying, collecting, and organizing the elements and issues involved. During the past thirty years, there have been significant advances in research methodology, many of them stimulated by multi-disciplinary collabo­ ration. The anticipated barriers to communication were not realized in prac­ tice. Scientists engaged in mutual problem-solving could accomplish more than their colleagues working in relative isolation. In the,r productive fashion, these multi-disciplinary teams, by pooling their knowledge sets and by devel­ oping communication mechanisms, created the interfaces between the clini­ cal, analytical, and communication sciences. These interfaces, while neither complete nor perfect, represent the methodology of interest in accomplishing the capture, evaluation, and utilization of information, or Information Process­ ing. The list of contributors to this methodology is virtually endless and we acknowledge their enormous and significant efforts.

• behavior
• clinical research
• clinical trial
• communication
• development
• diagnosis
• evaluation
• management
• methodology
• monitoring
• organizations
• planning
• research
• training
• translation

• School of Medicine, University of Southern California, Los Angeles, USA

  John M. Weiner

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