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Orotic Acid

Synthesis, Biochemical Aspects and Physiological Role

Authors: Cihák, A., Reutter, W.

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About this book

This volume reviews a series of different publications dealing with orotic acid. Orotic acid was isolated from cow's milk 75 years ago by Biscaro and Belloni in Italy. Fifty years later again Italian scientists described the growth-promoting activity of orotic acid in vitamin B -deficient animals. 12 Orotic acid is the precursor of pyrimidine nucleotides which are involved in many biochemical reactions: UTP and CTP, as substrates for RNA polymerase, and UDP sugars, as substrates for carbohydrate containing macromolecules, e.g. glycogen, glycoproteins and glycolipids. The biosynthesis of these pyrimidines is well regulated. Disturbance of the biosynthetic pathway or trapping of individual pyrimidine nucleotides may lead to severe metabolic and structural alterations of cells. Synthesis, biochemical aspects and physiological role are reviewed in nine chapters. In the last two decades increasing interest in orotic acid came from several studies showing protective or therapeutic or beneficial effects of this compound in different kinds of organ injuries: various forms of hepatic insufficiency, myocardial infarction, encephalopathy, memorization pro­ cesses, mentioned in Chapters 8 and 9. At the end of this overview a Bibliography in an alphabetical order with 673 references may give further insight in this topic.

Table of contents (9 chapters)

Table of contents (9 chapters)

Buy this book

eBook $59.99
price for USA in USD
  • ISBN 978-94-009-8043-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $79.99
price for USA in USD
  • ISBN 978-94-009-8045-7
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Orotic Acid
Book Subtitle
Synthesis, Biochemical Aspects and Physiological Role
Authors
Copyright
1980
Publisher
Springer Netherlands
Copyright Holder
A.?ihák and W. Reutter
eBook ISBN
978-94-009-8043-3
DOI
10.1007/978-94-009-8043-3
Softcover ISBN
978-94-009-8045-7
Edition Number
1
Number of Pages
VII, 118
Topics