Stereochemical Analysis of Alicyclic Compounds by C-13 NMR Spectroscopy

Authors: Whitesell, J. A.

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About this book

Through numerous conversations with other synthetic chemists it became apparent that the great power of carbon nuclear magnetic resonance was being significantly underutilized. In our own work we have found that 13C spectroscopy is a more powerful tool than IH NMR spectroscopy, especially for probing subtle stereochemical questions in complicated systems. This is especially true in five membered ring compounds where IH NMR is at a particular disadvantage. The two techniques can be used independently to solve the same question-that of stereochemistry - but they do so in different ways. Advantage can be taken in IH NMR of a relatively consistent relationship between stereochemical orientation and coupling constants between vicinal protons, while in 13C NMR it is the correlation between spatial relationships of non-hydrogen, y substituents and their effect on chemical shift that can be used to assign stereochemistry. It was also clear that the use of 13C NMR required a different approach to problem solving than that typically used with IH NMR. While the latter technique could be employed with a very general approach (e.g., the Karplus equation), 13C NMR would, at least for the immediate future, require a relatively extensive set of model systems from which the consequences of stereochemical changes could be derived for any given carbon framework.

Table of contents (19 chapters)

Table of contents (19 chapters)

Buy this book

eBook $74.99
price for USA in USD (gross)
  • ISBN 978-94-009-3161-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
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Bibliographic Information

Bibliographic Information
Book Title
Stereochemical Analysis of Alicyclic Compounds by C-13 NMR Spectroscopy
Authors
Copyright
1987
Publisher
Springer Netherlands
Copyright Holder
Chapman and Hall Ltd
eBook ISBN
978-94-009-3161-9
DOI
10.1007/978-94-009-3161-9
Edition Number
1
Topics