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Spotlight on Familial and Hereditary Gastric Cancer

  • Book
  • © 2013

Overview

Editors:
  1. Giovanni Corso

    1. Dept. of Medical, Surgical Sciences, and Neurosciences, University of Siena, Siena, Italy

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  2. Franco Roviello

    1. Dept. of Medical, Surgical Sciences, and Neurosciences, University of Siena, Siena, Italy

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  • Latest updated literature data and description of original data
  • The majority of the Authors are members of the International Gastric Cancer Linkage Consortium
  • New proposals for treatment and clinical management
  • Molecular medicine in clinical practice Novel classifications

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xviii
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  2. General Issues

    1. Front Matter

      Pages 1-1
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    2. Historical Overview of Familial Gastric Cancer

      • Giovanni Corso
      Pages 3-10

    3. Frequency of Familial Gastric Cancer

      • Giovanni Corso, Daniele Marrelli
      Pages 11-18

    4. The Family Cancer Database

      • Giovanni Corso, Daniele Marrelli, Franco Roviello
      Pages 19-23

  3. Genetics and Epigenetics

    1. Front Matter

      Pages 25-25
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    2. The E-Cadherin Gene, Structure and Function

      • Francesco Graziano
      Pages 27-33

    3. E-Cadherin Germline Mutations

      • Joana Carvalho, Hugo Pinheiro, Carla Oliveira
      Pages 35-49

    4. Molecular Mechanisms of Hereditary Diffuse Gastric Cancer Initiation and Progression

      • Parry Guilford, Bostjan Humar
      Pages 51-76

    5. Germline Missense Mutants in Hereditary Diffuse Gastric Cancer

      • Joana Figueiredo, Raquel Seruca
      Pages 77-86

    6. Alternative Mechanisms to Germline CDH1 Mutations in Hereditary Diffuse Gastric Cancer

      • Hugo Pinheiro, Joana Carvalho, Carla Oliveira
      Pages 87-96

    7. Beyond CDH1 Mutations: Causes of Hereditary Diffuse Gastric Cancer

      • Samantha Hansford, David Huntsman
      Pages 97-110

    8. Non-CDH1-Associated Familial Gastric Cancer and Epigenetics Factors

      • Marina Leite, Giovanni Corso, Sónia Sousa, Joana Carvalho, Franco Roviello, Carla Oliveira et al.
      Pages 111-125

  4. Pathology

    1. Front Matter

      Pages 127-127
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    2. Hereditary Diffuse Gastric Cancer and Lobular Breast Carcinoma

      • Gisela Keller
      Pages 129-139

    3. Pathology of Hereditary Gastric Cancer

      • Fátima Carneiro
      Pages 141-156

  5. Management

    1. Front Matter

      Pages 157-157
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    2. Clinical Criteria for Familial Gastric Cancer Definition

      • Giulia De Falco, Alessandro Davide Videtta
      Pages 159-165

    3. Prophylactic Total Gastrectomy in CDH1 Germline Mutation Carriers

      • Francesco Ferrara, Giovanni Corso, Franco Roviello
      Pages 167-176

    4. Gastric Cancer in Other Inherited Syndromes

      • Giovanni Corso, Sérgia Velho
      Pages 177-181
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Keywords

About this book

In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors. In particular, the aim of this novel editorial work is to propose the correct management of hereditary diffuse gastric cancer patients, focusing in particular on E-cadherin germline mutations, clinical criteria definition, genetic screening and molecular mechanisms, pathology and microscopic features, surgical treatment and clinical approach for asymptomatic mutation carriers. We also describe other inherited predispositions involving gastric carcinoma.

Editors and Affiliations

  • Dept. of Medical, Surgical Sciences, and Neurosciences, University of Siena, Siena, Italy

    Giovanni Corso, Franco Roviello

Bibliographic Information

  • Book Title: Spotlight on Familial and Hereditary Gastric Cancer

  • Editors: Giovanni Corso, Franco Roviello

  • DOI: https://doi.org/10.1007/978-94-007-6570-2

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2013

  • Hardcover ISBN: 978-94-007-6569-6Published: 18 June 2013

  • Softcover ISBN: 978-94-007-9715-4Published: 15 July 2015

  • eBook ISBN: 978-94-007-6570-2Published: 04 June 2013

  • Edition Number: 1

  • Number of Pages: XVIII, 211

  • Topics: Cancer Research, Biomedicine general, Gastroenterology, Human Genetics

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