Endoplasmic Reticulum Stress in Health and Disease

Editors: Agostinis, Patrizia, Afshin, Samali (Eds.)

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  • Comprehensive cover of the latest developments in ER stress
  • Up to date and succinct description of the role of ER stress in pathophysiology
  • Novel aspects of ER stress physiology never discussed before
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  • ISBN 978-94-007-4351-9
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Hardcover $249.99
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Softcover $199.99
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  • ISBN 978-94-007-9251-7
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About this book

The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Biology of the Endoplasmic Reticulum

    Pages 3-22

    Healy, Sandra JM (et al.)

  • A Tight-Knit Group: Protein Glycosylation, Endoplasmic Reticulum Stress and the Unfolded Protein Response

    Pages 23-39

    Gerlach, Jared Q (et al.)

  • ER Stress Signaling Pathways in Cell Survival and Death

    Pages 41-73

    Verfaillie, Tom (et al.)

  • Endoplasmic Reticulum-mitochondria connections, calcium cross-talk and cell fate: a closer inspection

    Pages 75-106

    Filadi, Riccardo (et al.)

  • ER Stress and UPR Through Dysregulated ER Ca

    Pages 107-142

    Vervliet, Tim (et al.)

Buy this book

eBook $149.00
price for USA in USD
  • ISBN 978-94-007-4351-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-94-007-4350-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $199.99
price for USA in USD
  • ISBN 978-94-007-9251-7
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Endoplasmic Reticulum Stress in Health and Disease
Editors
  • Patrizia Agostinis
  • Samali Afshin
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-4351-9
DOI
10.1007/978-94-007-4351-9
Hardcover ISBN
978-94-007-4350-2
Softcover ISBN
978-94-007-9251-7
Edition Number
1
Number of Pages
VIII, 452
Topics