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Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease

  • Book
  • © 2012

Overview

Editors:
  1. Tony Harris

    1. , Cell and Systems Biology, University of Toronto, Toronto, Canada

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  • Up-to-date reviews of adherens junction biology from internationally recognized experts in the field
  • Covers adherens junction biology from atoms to overall animal development and disease
  • A comprehensive resource for the research laboratory
  • A comprehensive teaching tool for advanced undergraduate and graduate courses in cell and developmental biology
  • Valuable for both newcomers and experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Subcellular Biochemistry (SCBI, volume 60)

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Table of contents (18 chapters)

  1. Front Matter

    Pages I-VI
    Download chapter PDF

  2. An Introduction to Adherens Junctions: From Molecular Mechanisms to Tissue Development and Disease

    • Tony J. C. Harris
    Pages 1-5

  3. How AJs Evolved

    1. Front Matter

      Pages 7-7
      Download chapter PDF

    2. Evolution of the Cadherin–Catenin Complex

      • Oda Hiroki
      Pages 9-35

  4. How Cadherins and Catenins Interact to Assemble AJs

    1. Front Matter

      Pages 37-37
      Download chapter PDF

    2. The Three-Dimensional Structure of the Cadherin–Catenin Complex

      • Noboru Ishiyama, Mitsuhiko Ikura
      Pages 39-62

    3. Biophysics of Cadherin Adhesion

      • Deborah Leckband, Sanjeevi Sivasankar
      Pages 63-88

    4. Adherens Junction Assembly

      • Sergey Troyanovsky
      Pages 89-108

  5. How AJs Interface with Other Cellular Machinery

    1. Front Matter

      Pages 109-109
      Download chapter PDF

    2. The Cytoskeleton and Classical Cadherin Adhesions

      • Siew Ping Han, Alpha S. Yap
      Pages 111-135

    3. Immunoglobulin Superfamily Receptors and Adherens Junctions

      • Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori, Yoshimi Takai
      Pages 137-170

    4. Signaling from the Adherens Junction

      • Abbye E. McEwen, David E. Escobar, Cara J. Gottardi
      Pages 171-196

    5. Adherens Junction Turnover: Regulating Adhesion Through Cadherin Endocytosis, Degradation, and Recycling

      • Andrew P. Kowalczyk, Benjamin A. Nanes
      Pages 197-222

  6. How AJs Affect Cell Behaviour and Multicellular Development

    1. Front Matter

      Pages 223-223
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    2. Adherens Junctions During Cell Migration

      • Sandrine Etienne-Manneville
      Pages 225-249

    3. Adherens Junctions and Cadherins in Drosophila Development

      • Annalisa Letizia, Marta Llimargas
      Pages 251-277

    4. Adherens Junctions in C. elegans Embryonic Morphogenesis

      • Stephen T. Armenti, Jeremy Nance
      Pages 279-299

    5. Cadherin Function During Xenopus Gastrulation

      • Rudolf Winklbauer
      Pages 301-320

    6. Adherens Junctions in Mammalian Development, Homeostasis and Disease: Lessons from Mice

      • Barbara Boggetti, Carien M. Niessen
      Pages 321-355

  7. How AJs Affect Tissue Homeostasis and Disease

    1. Front Matter

      Pages 357-357
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Keywords

About this book

Cell–cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology.
• How did AJs evolve?
• How do cadherins and catenins interact to assemble AJs and mediate adhesion?
• How do AJs interface with other cellular machinery to couple adhesion with the whole cell?
• How do AJs affect cell behaviour and multicellular development?
• How can abnormal AJ activity lead to disease?

Editors and Affiliations

  • , Cell and Systems Biology, University of Toronto, Toronto, Canada

    Tony Harris

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