Phosphoinositides I: Enzymes of Synthesis and Degradation
Editors: Balla, Tamas, Wymann, Matthias, York, John D. (Eds.)
Free Preview- In depth discussion of the state of the art of phosphoinositide research
- Experts in the field discussing the 'hot' topics in phosphoinositide research
- A volume dedicated to the enzymes involved in the synthesis and degradation of phosphoinositides
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- About this book
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Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
- Table of contents (9 chapters)
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The Phosphatidylinositol 4-Kinases: Don’t Call it a Comeback
Pages 1-24
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PIP Kinases from the Cell Membrane to the Nucleus
Pages 25-59
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The Phospholipase C Isozymes and Their Regulation
Pages 61-94
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Phosphoinositide 3-Kinases—A Historical Perspective
Pages 95-110
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PI3Ks—Drug Targets in Inflammation and Cancer
Pages 111-181
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Table of contents (9 chapters)
- Download Preface 1 PDF (200.9 KB)
- Download Sample pages 1 PDF (1.2 MB)
- Download Table of contents PDF (160.5 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Phosphoinositides I: Enzymes of Synthesis and Degradation
- Editors
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- Tamas Balla
- Matthias Wymann
- John D. York
- Series Title
- Subcellular Biochemistry
- Series Volume
- 58
- Copyright
- 2012
- Publisher
- Springer Netherlands
- Copyright Holder
- Springer Science+Business Media B.V.
- eBook ISBN
- 978-94-007-3012-0
- DOI
- 10.1007/978-94-007-3012-0
- Hardcover ISBN
- 978-94-007-3011-3
- Softcover ISBN
- 978-94-017-8157-2
- Series ISSN
- 0306-0225
- Edition Number
- 1
- Number of Pages
- XVI, 356
- Topics
