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Stem Cells and Cancer Stem Cells, Volume 4

Therapeutic Applications in Disease and Injury

  • Book
  • © 2012

Overview

Editors:
  1. M.A. Hayat

    1. , Kean University, Room 213, Library building, Union, USA

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  • Tissue engineering is explained in detail
  • Role of regenerative medicine in therapy
  • Stem cell transplantation to heal tissue injury
  • Target medicine Translational medicine
  • Role of cancer stem cells in disease such as breast cancer

Part of the book series: Stem Cells and Cancer Stem Cells (STEM, volume 4)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xix
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  2. Molecular Genetic

    1. Front Matter

      Pages 1-1
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    2. Neural Stem/Progenitor Cell Proliferation and Differentiation: Role of Sonic Hedgehog and Wingless/Int-1 Proteins

      • Miroslava Anderova, Pavel Honsa
      Pages 3-18

    3. Sensitivity of Hematopoietic and Leukemic Stem Cells to Hoxa Gene Levels

      • Charles-Etienne Lebert-Ghali, Joanne Margaret Ramsey, Alexander Thompson, Janetta Bijl
      Pages 19-29

    4. Maintenance of Neural Stem Cells in the Brain: Role of Notch Signaling

      • Ryoichiro Kageyama, Hiromi Shimojo, Toshiyuki Ohtsuka, Itaru Imayoshi
      Pages 31-39

    5. Maintenance of Hematopoiesis: Role of Early B Cell Factor 2

      • Matthias Kieslinger
      Pages 41-50

    6. Differentiation of Periodontal Ligament Stem/Progenitor Cells: Roles of TGF-β1

      • Hidefumi Maeda, Shinsuke Fujii, Satoshi Monnouchi, Naohisa Wada, Akifumi Akamine
      Pages 51-58

    7. Induced Pluripotent Stem Cells from Human Extra-Embryonic Amnion Cells: Role of DNA Methylation in Maintaining Stemness

      • Koichiro Nishino, Akihiro Umezawa
      Pages 59-65

    8. Smooth Muscle Cell Differentiation from Embryonic Stem Cells: Role of HDAC7 and PDGF-BB

      • David Sims, Qingzhong Xiao
      Pages 67-76

    9. Adult Neural Stem Cells; Identity and Regulation

      • Tetsuya Imura
      Pages 77-84

  3. Regenerative Medicine

    1. Front Matter

      Pages 85-85
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    2. Tendon Injury: Role of Differentiation of Adult and Embryonic Derived Stem Cells

      • Yin Zi, Chen Xiao, Boon Chin Heng, Hong Wei Ouyang
      Pages 87-95

    3. The Potential of Stem Cells and Tissue Engineered Scaffolds for Repair of the Central Nervous System

      • Alexandra L. Rodriguez, David R. Nisbet, Clare L. Parish
      Pages 97-111

    4. Improving the Efficacy of Diabetes Mellitus Treatment by Combining Cell Replacement Therapy with Immune Correction

      • Pham Van Phuc, Phan Kim Ngoc
      Pages 113-124

    5. Induced Pluripotent Stem Cell Production and Characterization: An Overview of Somatic Cell Reprogramming

      • Jesse L. Cox, Angie Rizzino
      Pages 125-137

    6. Proliferation of Bone Marrow-Derived Human Mesenchymal Stem Cells: Role of Enamel Matrix Proteins

      • Kotaro Tanimoto, Yu-Ching Huang, Kazuo Tanne
      Pages 139-145

    7. Pluripotent Cell-Derived Glial Precursor Cells for the Delivery of Therapeutic Proteins to the Central Nervous System

      • Aaron J. Robinson, Joy Rathjen
      Pages 147-160

    8. Cellularized Scaffolds: New Clothes for Cardiac Regenerative Medicine

      • Kee Pah Lim, Ling Qian, Philip Wong, Winston Shim
      Pages 161-174

    9. Microencapsulation Procedures for the Immunoisolation of Wharton’s Jelly Mesenchymal Stem Cells: A Review

      • Stefania Mazzitelli, Renata Vecchiatini, Letizia Penolazzi, Elisabetta Lambertini, Roberta Piva, Claudio Nastruzzi
      Pages 175-191

  4. Therapy

    1. Front Matter

      Pages 193-193
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Keywords

About this book

Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, induced pluripotent stem cells, human hair follicle stem cells, bone marrow-derived human mesenchymal stem cells, adipose-derived stem cells, periodontal/progenitor cells, cancer stem cells, and breast cancer stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on this type of stem cells in this volume. The role of cancer stem cells, specifically in breast cancer is explained. Transplantation of mesenchymal stem cells to aid the injured brain is included. Immune recovery after stem cells transplantation in severe combined immunodeficiency patients is described. The role of mesenchymal stem cells in enhancing the growth and metastasis of colon cancer is discussed. Clinical application of human follicle stem cells is presented. Treatment of malignant gliomas using genetically-modified neural stem cells as a marker is discussed. The impact of cancer stem cell hypothesis on designing new cancer therapies is explained. In the field of regenerative medicine, the use of stem cells in the repair of the central nervous system, tendon injury, and as a cardiac regenerative medicine is described. The role of DNA methylation in maintaining stemness induced pluripotent stem cells from human extraembryonic amnion cells is discussed. Insights on the understanding of molecular pathways involved in tumor biology are explained, which lead to the development of effective drugs. Information on pathways, such as hedgehog, facilitates targeted therapies in cancer.

Editors and Affiliations

  • , Kean University, Room 213, Library building, Union, USA

    M.A. Hayat

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