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Tumors of the Central Nervous System, Volume 1

Gliomas: Glioblastoma (Part 1)

  • Book
  • © 2011

Overview

Editors:
  1. M. A. Hayat

    1. Dept. Biological Sciences, Kean University, Union, USA

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  • Targeted therapy determined by molecular genetics is emphasized
  • Role of molecular genetics in the CNS cancer development is discussed
  • Advantages and limitations of biomarkers in tumor detection and diagnosis are detailed
  • The role of translational medicine is emphasized (bench to bed)
  • Can be used as an outside reading to obtain additional information at seminars and conferences in the medical field
  • Teachers in medicine would be interested

Part of the book series: Tumors of the Central Nervous System (TCNS, volume 1)

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Table of contents (42 chapters)

  1. Front Matter

    Pages i-xxi
    Download chapter PDF

  2. Introduction

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Introduction

      • M.A. Hayat
      Pages 3-8

    3. Molecular Classification of Gliomas

      • Kikuya Kato
      Pages 9-19

  3. Biomarkers and Diagnosis

    1. Front Matter

      Pages 21-21
      Download chapter PDF

    2. Glioblastoma: Endosialin Marker for Pericytes

      • Nicole Simonavicius, Clare M. Isacke, Ivo J. Huijbers
      Pages 23-29

    3. Glioma Grading Using Cerebral Blood Volume Heterogeneity

      • Kyrre E. Emblem, Atle Bjornerud
      Pages 31-43

    4. The Role of Ectonucleotidases in Glioma Cell Proliferation

      • Elizandra Braganhol, Andressa Bernardi, Angélica R. Cappellari, Márcia R. Wink, Ana M.O. Battastini
      Pages 45-51

    5. Gliomas: Role of Monoamine Oxidase B in Diagnosis

      • Luis F. Callado, Jesús M. Garibi, J. Javier Meana
      Pages 53-59

    6. Glioma: Role of Integrin in Pathogenesis and Therapy

      • Ming-Tao Yang, Tur-Fu Huang, Wen-Mei Fu
      Pages 61-66

    7. Proton Magnetic Resonance Spectroscopy in Intracranial Gliomas

      • Eftychia Z. Kapsalaki, Ioannis Tsougos, Kyriaki Theodorou, Kostas N. Fountas
      Pages 67-79

    8. Infiltration Zone in Glioma: Proton Magnetic Resonance Spectroscopic Imaging

      • Oliver Ganslandt, A. Stadlbauer
      Pages 81-88

    9. Malignant Gliomas: Role of E2F1 Transcription Factor

      • Marta M. Alonso, Juan Fueyo, Candelaria Gomez-Manzano
      Pages 89-97

    10. The Role of Glucose Transporter-1 (GLUT-1) in Malignant Gliomas

      • Randy L. Jensen, Rati Chkheidze
      Pages 99-108

    11. Malignant Gliomas: Role of Platelet-Derived Growth Factor Receptor A (PDGFRA)

      • Olga Martinho, Rui Manuel Reis
      Pages 109-118

    12. Molecular Methods for Detection of Tumor Markers in Glioblastomas

      • Marie E. Beckner, Mary L. Nordberg
      Pages 119-130

    13. Role of MGMT in Glioblastomas

      • Izabela Zawlik, Dorota Jesionek-Kupnicka, Pawel P. Liberski
      Pages 131-136

    14. Glioblastomas: Role of CXCL12 Chemokine

      • Yasuo Sugita
      Pages 137-146

    15. Cell Death Signaling in Glioblastoma Multiforme: Role of the Bcl2L12 Oncoprotein

      • Alexander H. Stegh
      Pages 147-157

    16. Glioblastoma Multiforme: Role of Polycomb Group Proteins

      • Sabrina Facchino, Mohamed Abdouh, Gilbert Bernier
      Pages 159-166
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Keywords

About this book

The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers is included. The identification and validation of brain cancer (glioblastoma) genes are discussed. Role of cancer stem cells in the initiation, progression, and persistence of malignant gliomas is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed.

Reviews

From the reviews:

“This is an outstanding book on every molecular mediator of cancer stem cells, angiogenesis, surface markers, and CAD mediators of oncogenesis in the brain. … This is a very good book for neuropathologists and neurosurgeons.” (Joseph J. Grenier, Amazon.com, June, 2014)

Editors and Affiliations

  • Dept. Biological Sciences, Kean University, Union, USA

    M. A. Hayat

Bibliographic Information

  • Book Title: Tumors of the Central Nervous System, Volume 1

  • Book Subtitle: Gliomas: Glioblastoma (Part 1)

  • Editors: M. A. Hayat

  • Series Title: Tumors of the Central Nervous System

  • DOI: https://doi.org/10.1007/978-94-007-0344-5

  • Publisher: Springer Dordrecht

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2011

  • Hardcover ISBN: 978-94-007-0343-8Published: 23 March 2011

  • Softcover ISBN: 978-94-007-3558-3Published: 23 April 2013

  • eBook ISBN: 978-94-007-0344-5Published: 23 March 2011

  • Series ISSN: 2215-096X

  • Series E-ISSN: 2215-0978

  • Edition Number: 1

  • Number of Pages: XXII, 434

  • Topics: Cancer Research, Neuroradiology, Neurosurgery, Oncology, Pathology, Surgery

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