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The Minimal Cell

The Biophysics of Cell Compartment and the Origin of Cell Functionality

Editors: Luisi, Pier Luigi, Stano, Pasquale (Eds.)

  • Up-to-date view of experimental research on the construction of advanced cell models based on liposomes
  • Presents biophysical, biochemical, genetic and computational approaches
  • Applies modern approaches to the physics underlying the origins of primitive cells
  • Emphasizes the role of compartmentation and its consequences in properties, reactivity, organization, evolution
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-90-481-9944-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-90-481-9943-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-94-017-8158-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In the last ten years there has been a considerable increase of interest on the notion of the minimal cell. With this term we usually mean a cell-like structure containing the minimal and sufficient number of components to be defined as alive, or at least capable of displaying some of the fundamental functions of a living cell. In fact, when we look at extant living cells we realize that thousands of molecules are organized spatially and functionally in order to realize what we call cellular life. This fact elicits the question whether such huge complexity is a necessary condition for life, or a simpler molecular system can also be defined as alive. Obviously, the concept of minimal cell encompasses entire families of cells, from totally synthetic cells, to semi-synthetic ones, to primitive cell models, to simple biomimetic cellular systems. Typically, in the experimental approach to the construction of minimal the main ingredient is the compartment. Lipid vesicles (liposomes) are used to host simple and complex molecular transformations, from single or multiple enzymic reactions, to polymerase chain reactions, to gene expression. Today this research is seen as part of the broader scenario of synthetic biology but it is rooted in origins of life studies, because the construction of a minimal cell might provide biophysical insights into the origins of primitive cells, and the emergence of life on earth. The volume provides an overview of physical, biochemical and functional studies on minimal cells, with emphasis to experimental approaches. 15 International experts report on their innovative contributions to the construction of minimal cells.

Table of contents (15 chapters)

  • Towards a Minimal Cytoplasm

    Keighron, Jacqueline D. (et al.)

    Pages 3-30

  • Evolution of the Cell’s Mechanical Design

    Boal, David (et al.)

    Pages 31-50

  • On the Minimal Requirements for the Emergence of Cellular Crowding

    Acerenza, Luis (et al.)

    Pages 51-64

  • How Small is Small?

    Moore, Peter B.

    Pages 65-71

  • Biochemical Reactions in the Crowded and Confined Physiological Environment: Physical Chemistry Meets Synthetic Biology

    Minton, Allen P. (et al.)

    Pages 73-89

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-90-481-9944-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-90-481-9943-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-94-017-8158-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Minimal Cell
Book Subtitle
The Biophysics of Cell Compartment and the Origin of Cell Functionality
Editors
  • Pier Luigi Luisi
  • Pasquale Stano
Copyright
2011
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-90-481-9944-0
DOI
10.1007/978-90-481-9944-0
Hardcover ISBN
978-90-481-9943-3
Softcover ISBN
978-94-017-8158-9
Edition Number
1
Number of Pages
X, 298
Topics