Functional and Structural Proteomics of Glycoproteins

1. Front Matter

   Pages i-x

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2. Glycoproteomics in Health and Disease

   • Weston B. Struwe, Eoin F.J. Cosgrave, Jennifer C. Byrne, Radka Saldova, Pauline M. Rudd

   Pages 1-38

3. Glyco-engineering of Fc Glycans to Enhance the Biological Functions of Therapeutic IgGs

   • T. Shantha Raju, David M. Knight, Robert E. Jordan

   Pages 39-58

4. Bioinformatics Databases and Applications Available for Glycobiology and Glycomics

   • René Ranzinger, Kai Maaß, Thomas Lütteke

   Pages 59-90

5. Lectin Microarrays: Simple Tools for the Analysis of Complex Glycans

   • Lakshmi Krishnamoorthy, Lara K. Mahal

   Pages 91-102

6. The Application of High Throughput Mass Spectrometry to the Analysis of Glycoproteins

   • Sasha Singh, Morten Thaysen Andersen, Judith Jebanathirajah Steen

   Pages 103-125

7. Solutions to the Glycosylation Problem for Low- and High-Throughput Structural Glycoproteomics

   • Simon J. Davis, Max Crispin

   Pages 127-158

8. Role of Glycoproteins in Virus–Human Cell Interactions

   • Thomas A. Bowden, Elizabeth E. Fry

   Pages 159-180

9. Back Matter

   Pages 181-181

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It has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. For example, the glycans attached to proteins have emerged as important biomarkers in the diagnosis of diseases such as cancers and play a significant role in how pathogenic viruses gain entry into human cells. The study of glycoproteins has now become a truly proteomic science. In the last few years, technology developments including in silico methods, high throughput separation and detection techniques have accelerated the characterization of glycoproteins in cells and tissues. Glyco-engineering coupled to rapid recombinant protein production has facilitated the determination of glycoprotein structures key to exploring and exploiting their functional roles. Each chapter in this volume is written by experts in the field and together provide a review of the state of the art in the emerging field of glycoproteomics.

• Glycans
• Glycobiology
• Glycomics
• Glycoproteins
• Glycoproteomics

• Oxford Protein Production Facility, Oxford, United Kingdom

  Raymond Owens, Joanne Nettleship

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