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Functional and Structural Proteomics of Glycoproteins

  • Book
  • © 2011

Overview

Editors:
  1. Raymond Owens

    1. Oxford Protein Production Facility, Oxford, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  2. Joanne Nettleship

    1. Oxford Protein Production Facility, Oxford, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  • Covers a broad range of technologies
  • Comprehensive articles written by international experts in the field of glycoproteomics
  • A timely review of glycoproteins and methods for the diagnosis and treatment of glycoprotein related human diseases

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-x
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  2. Glycoproteomics in Health and Disease

    • Weston B. Struwe, Eoin F.J. Cosgrave, Jennifer C. Byrne, Radka Saldova, Pauline M. Rudd
    Pages 1-38

  3. Glyco-engineering of Fc Glycans to Enhance the Biological Functions of Therapeutic IgGs

    • T. Shantha Raju, David M. Knight, Robert E. Jordan
    Pages 39-58

  4. Bioinformatics Databases and Applications Available for Glycobiology and Glycomics

    • René Ranzinger, Kai Maaß, Thomas Lütteke
    Pages 59-90

  5. Lectin Microarrays: Simple Tools for the Analysis of Complex Glycans

    • Lakshmi Krishnamoorthy, Lara K. Mahal
    Pages 91-102

  6. The Application of High Throughput Mass Spectrometry to the Analysis of Glycoproteins

    • Sasha Singh, Morten Thaysen Andersen, Judith Jebanathirajah Steen
    Pages 103-125

  7. Solutions to the Glycosylation Problem for Low- and High-Throughput Structural Glycoproteomics

    • Simon J. Davis, Max Crispin
    Pages 127-158

  8. Role of Glycoproteins in Virus–Human Cell Interactions

    • Thomas A. Bowden, Elizabeth E. Fry
    Pages 159-180

  9. Back Matter

    Pages 181-181
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Keywords

About this book

It has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. For example, the glycans attached to proteins have emerged as important biomarkers in the diagnosis of diseases such as cancers and play a significant role in how pathogenic viruses gain entry into human cells. The study of glycoproteins has now become a truly proteomic science. In the last few years, technology developments including in silico methods, high throughput separation and detection techniques have accelerated the characterization of glycoproteins in cells and tissues. Glyco-engineering coupled to rapid recombinant protein production has facilitated the determination of glycoprotein structures key to exploring and exploiting their functional roles. Each chapter in this volume is written by experts in the field and together provide a review of the state of the art in the emerging field of glycoproteomics.

Editors and Affiliations

  • Oxford Protein Production Facility, Oxford, United Kingdom

    Raymond Owens, Joanne Nettleship

Bibliographic Information

  • Book Title: Functional and Structural Proteomics of Glycoproteins

  • Editors: Raymond Owens, Joanne Nettleship

  • DOI: https://doi.org/10.1007/978-90-481-9355-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2011

  • Hardcover ISBN: 978-90-481-9354-7Published: 07 December 2010

  • Softcover ISBN: 978-94-007-9040-7Published: 23 November 2014

  • eBook ISBN: 978-90-481-9355-4Published: 02 December 2010

  • Edition Number: 1

  • Number of Pages: X, 181

  • Topics: Biochemistry, general

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