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CCN proteins in health and disease

An overview of the Fifth International Workshop on the CCN family of genes

Editors: Perbal, Annick, Takigawa, Masaharu, Perbal, Bernard (Eds.)

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  • Unique book volume on the 2008 CCN SOciety Conference

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  • ISBN 978-90-481-3779-4
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Hardcover $249.99
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Softcover $219.99
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  • ISBN 978-94-017-8291-3
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About this book

The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors.

The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types.

The 5th international workshop on the CCN family of genes, that was held in Toronto in 2008 brought together scientists from around the world who have an interest in the biological roles of this emerging family of proteins. On an educational point of view, the workshop was a unique place for an efficient diffusion of scientific information.

The present book comprises a series of selected manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology.

All major aspects of CCN proteins biology in both normal and pathological conditions are covered in this volume, from structure-functions analysis up to the involvement of CCN proteins in complex physiological functions.

In addition to reports that support the Yin-Yang concept of CCN proteins driving opposite effects on the same biological process, this book also comprises several contributions that point to CCN proteins as amenable targets for therapeutic manipulation of disease processes.

Together with the special issue of Journal of Cell Communication and Signaling in which authors have extended on the original data presented at the meeting, the present Proceedings provide an instant picture and unique update of the state of the art in the CCN field.

Table of contents (19 chapters)

Table of contents (19 chapters)
  • A Recent Breakthrough in the CCN Field: Functional Interactions Between CCN2 and CCN3 are Uncovered

    Pages 1-4

    Perbal, Bernard

  • Report on the Fifth International Workshop on the CCN Family of Genes

    Pages 5-13

    Irvine, A. E. (et al.)

  • Asking the Right Questions: What Can the Structure of the CCN Protein Domains Tell Us?

    Pages 15-40

    Holbourn, Kenneth P. (et al.)

  • Nucleophosmin/B23: A Multifunctional Regulator that Determines the Fate of CCN2 mRNA

    Pages 41-55

    Kubota, Satoshi (et al.)

  • The CCN Genes as the “Master” Regulators of Angiogenesis, Vasculogenesis, Fibrogenesis and Cell Differentiation/Fate Specification in Mechanical Force-Driven Developmental Processes and Pathological Events

    Pages 57-76

    Hanna, Mary (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-90-481-3779-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-90-481-3778-7
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $219.99
price for USA in USD
  • ISBN 978-94-017-8291-3
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
CCN proteins in health and disease
Book Subtitle
An overview of the Fifth International Workshop on the CCN family of genes
Editors
  • Annick Perbal
  • Masaharu Takigawa
  • Bernard Perbal
Copyright
2010
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-90-481-3779-4
DOI
10.1007/978-90-481-3779-4
Hardcover ISBN
978-90-481-3778-7
Softcover ISBN
978-94-017-8291-3
Edition Number
1
Number of Pages
XIII, 338
Topics