Advances in the Immunopathogenesis of Multiple Sclerosis

Editors: Gambi, Domencio, Lugaresi, Allesandra, Muraro, Paolo A. (Eds.)

Free Preview

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-88-470-2269-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-88-470-0067-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

P.A. MURARO, A. LUGARESI, D. GAMBI Many of the pathological aspects of multiple sclerosis (MS) lesions have been known for over a century. It is only recently, however, that different patterns of demyelination have been linked to distinct pathways of immune-mediated tissue destruction. In particular, the inter-individual heterogeneity of MS lesions has suggested that different mechanisms may act in different patients, accounting for the variability observed in clinical course, immunological findings in peripheral blood and cere­ brospinal fluid (CSF), and response to immunomodulatory treatments. To provide an overview of the basic mechanisms possibly involved in MS lesion initiation and development, an international meeting was organized in the context of the annual Congress of the Italian Neuroimmunology Association (AINI), held at the University of Chieti, in Chieti Italy on 29 October 1998. The high standard of presentations prompted us to report them in extended form, to highlight recent pro­ gress in the understanding of basic mechanisms sustaining MS immuno­ pathogenesis. A central role in the possible mechanisms leading to myelin destruc­ tion has been attributed to T lymphocytes reactive to myelin antigens. Studies on the myelin antigen-specific T cell repertoire have contributed significant advances to our knowledge of autoimmunity (Chapters 1,2).

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Introduction

    Muraro, P. A. (et al.)

    Pages 1-2

  • The affinity spectrum of myelin basic protein-reactive T cells

    Mazzanti, B. (et al.)

    Pages 3-9

  • The naïve and memory MBP-reactive CD4+ T cell repertoire: implications for the autoimmune concept in multiple sclerosis

    Muraro, P. A. (et al.)

    Pages 11-19

  • From specificity to degeneracy to molecular mimicry: antigen recognition of human autoreactive and pathogen-specific CD4+ T cells

    Hemmer, B. (et al.)

    Pages 21-28

  • Immune activation in the interface between innate immunity and adaptive response:in vitro studies and therapeutical implications

    Ristori, G. (et al.)

    Pages 29-35

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-88-470-2269-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-88-470-0067-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Advances in the Immunopathogenesis of Multiple Sclerosis
Editors
  • Domencio Gambi
  • Allesandra Lugaresi
  • Paolo A. Muraro
Copyright
1999
Publisher
Springer-Verlag Mailand
Copyright Holder
Springer-Verlag Italia, Milan
eBook ISBN
978-88-470-2269-0
DOI
10.1007/978-88-470-2269-0
Softcover ISBN
978-88-470-0067-4
Edition Number
1
Number of Pages
90
Number of Illustrations
6 b/w illustrations
Topics