Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight

Editors: Kalia, Vipin Chandra (Ed.)

  • Defines quorum sensing (QS) systems as the global regulators of bacterial genes expression
  • Discusses the potential of QS regulation as a new drug target for the treatment of bacterial infections
  • Addresses to the increasing demand of antibiotic-resistant bacteria for novel strategies to control infectious diseases
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  • ISBN 978-81-322-1982-8
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Hardcover $219.99
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Softcover $169.99
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  • ISBN 978-81-322-3548-4
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About this book

Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?

About the authors

Dr. Vipin Chandra Kalia is presently working as Chief Scientist, Microbial Biotechnology and Genomics, CSIR- Institute of Genomics and Integrative Biology. He is a Professor, AcSIR who obtained his M.Sc. and Ph.D. Genetics, from Indian Agricultural Research Institute, New Delhi. He has been elected as: (i) Fellow of Association of Microbiologists of India (FAMI), and (ii) Fellow of National Academy of Sciences (FNASc). His main areas of Research are Microbial Biodiversity, Bioenergy, Biopolymers, Genomics and Microbial Evolution; Quorum sensing, Quorum quenching, Drug Discovery and Antimicrobials. He has published 65 papers in Scientific journals such as (i) Nature Biotechnology, (ii) Biotechnology Advances, (iii) Trends in Biotechnology, (iv) Critical Reviews in Microbiology, (v) Bio resource Technology, (vi) PLoS ONE, (vii) BMC Genomics. His works have been cited 1600 times with an h index: 22; i10 index: 35. He is presently the Editor in Chief of Indian Journal of Microbiology and Editor of (i) J Microbiol & Biotechnol(Korea), (ii). Appl. Biochem. & Biotechnology (USA), (iii) International Scholarly Res. Network Renewable Energy, (iv). Dataset Papers in Microbiol. Life member of Scientific Societies: (i) Society of Biological Chemists of India (ii) Society for Plant Biochem. & Biotechnol. (India); (iii) Association of Microbiologist of India; (iv) Indian Science Congress Association; (v) BioEnergy Society of India, (vi) Biotech Res. Soc. of India. (BRSI); Member: American Society of Microbiology. He can be contacted at: vckalia@igib.res.in; vc_kalia@yahoo.co.in

Table of contents (31 chapters)

  • Microbes: The Most Friendly Beings?

    Kalia, Vipin C.

    Pages 1-5

  • Evolution of MDRs

    Bhardwaj, Ashima Kushwaha (et al.)

    Pages 9-22

  • Biofilms: Maintenance, Development, and Disassembly of Bacterial Communities Are Determined by QS Cascades

    Ganin, Hadas (et al.)

    Pages 23-37

  • Quorum Sensing in Pathogenesis and Virulence

    Viswanathan, Pragasam (et al.)

    Pages 39-50

  • Quorum Sensing in Nitrogen Fixation

    Gao, Jie (et al.)

    Pages 51-60

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-81-322-1982-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-81-322-1981-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-81-322-3548-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight
Editors
  • Vipin Chandra Kalia
Copyright
2015
Publisher
Springer India
Copyright Holder
Springer India
eBook ISBN
978-81-322-1982-8
DOI
10.1007/978-81-322-1982-8
Hardcover ISBN
978-81-322-1981-1
Softcover ISBN
978-81-322-3548-4
Edition Number
1
Number of Pages
XI, 391
Number of Illustrations and Tables
52 b/w illustrations, 42 illustrations in colour
Topics