Omics for Personalized Medicine

1. Front Matter

   Pages i-xviii

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2. General Aspects of Pharmacogenomics

   1. Front Matter

      Pages 1-1

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   2. Pharmacogenomics, Pharmacoproteomics, and Pharmacometabolomics and Personalized Medicine: An Overview

      • Nalini Raghavachari, Marjan Gucek

      Pages 3-18

   3. Personalized Genome, Current Status, and the Future of Pharmacogenomics

      • Rohan Mitra, Mohan Lal Gope, Rajalakshmi Gope

      Pages 19-37

   4. Next-Generation Sequencing (NGS): A Revolutionary Technology in Pharmacogenomics and Personalized Medicine

      • Huixiao Hong, Wenqian Zhang, Zhenqiang Su, Jie Shen, Weigong Ge, Baitang Ning et al.

      Pages 39-61

   5. Pharmaco-epigenomics

      • Mehmet Gunduz, Muradiye Acar, Kubra Erdogan, Elif Nihat Cetin, Esra Gunduz

      Pages 63-75

   6. Personalized Nutrition and Drug–Nutrient Interactions

      • Yousef I. Hassan

      Pages 77-95

   7. Designing and Implementing Pharmacogenomics Study

      • Yeşim Aydın Son, Şükrü Tüzmen, Candan Hızel

      Pages 97-122

   8. Omics Approaches and Applications in Clinical Trials

      • Sanjeev Sharma, Anjana Munshi

      Pages 123-145

   9. Ethical Considerations in Pharmacogenomics

      • Anjana Munshi, Yog Raj Ahuja

      Pages 147-161

   10. Computational Pharmacogenomics

       • Enrique Hernández-Lemus

       Pages 163-186

   11. Pharmacogenomics in the Era of Personal Genomics: A Quick Guide to Online Resources and Tools

       • Ayesha Pasha, Vinod Scaria

       Pages 187-211

3. Personalized Medicine: Cancer and Autoimmune Disorders

   1. Front Matter

      Pages 213-213

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   2. Pharmacogenomics and Personalized Medicine for Cancer

      • Dipali Dhawan, Harish Padh

      Pages 215-235

   3. Pharmacogenomics in Acute Myeloid Leukemia

      • Omer Faruk Hatipoglu, Onur Bender, Esra Gunduz, Mehmet Gunduz

      Pages 237-248

   4. Pharmacogenomics of Autoimmune Diseases

      • Melvin George, Sandhiya Selvarajan, Suresh Kumar Srinivasamurthy

      Pages 249-262

4. Personalized Medicine: Neuro and Psychiatric Disorders

   1. Front Matter

      Pages 263-263

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   2. Pharmacogenomics and Personalized Medicine in Parkinsonism

      • Trevor Archer, Anders Fredriksson

      Pages 265-287

   3. Pharmacogenomics and Personalized Medicine in Alzheimer’s Disease

      • Trevor Archer, Boo Johansson

      Pages 289-308

   4. Pharmacogenomics and Personalized Medicine in Mood Disorders

      • Trevor Archer, Serafino Ricci, Max Rapp Ricciardi

      Pages 309-334

“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

• Genotype
• Nutrition
• Pharmaco-geno-proteo-metabolomic
• Metabolomics

• Centre for Genomics & Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Purba Medinipur, India

  Debmalya Barh

• Institute of Life Sciences, B.V. Patel Pharmaceutical Education and Research Development Centre, Ahmedabad University, Ahmedabad, India

  Dipali Dhawan

• Policy Centre for Biomedical Research, Translational Health Science and Technology Institute (Department of Biotechnology Institute, Government of India), Office @ National Institute of Immunology, New Delhi, India

  Nirmal Kumar Ganguly

Debmalya Barh is the Founder and President of the Institute of Integrative Omics and Applied Biotechnology (IIOAB), India, and a consultant biotechnologist having international repute. He is an active researcher in multidisciplinary “omics” fields that include biomarkers, target and targeted drug discovery, pharmacogenomics, neutrigenomics, neuroscience, cancer, and cardiovascular, infectious, and metabolic diseases. He works with nearly 300 researchers from 18 to 20 countries and has published more than 100 papers. He is a well known editor for many research reference books in the foremost domains of “Omics” published by top-ranked international publishers.
Dipali Dhawan is a promising researcher in the field of Pharmacogenomics, and Induced Pluripotent and Cancer Stem Cells. A postgraduate in Molecular and Genetic Medicine from University of Sheffield, UK and a PhD in Biotechnology from Nirma University, India, Dr. Dhawan is presently associated with the Institute of Life Sciences, Ahmedabad University,  India. She has published many research works and has also been awarded CSIR and DST fellowships.

Prof. Nirmal Kumar Ganguly is a distinguished Biotechnology Research Professor, Department of Biotechnology (DBT), GoI. He is the President of Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), as well as that of the Asian Institute of Public Health, Bhubaneswar, Odisha. He is the former Director General of ICMR, New Delhi, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, and National Institute of Biologicals (NIB), Noida. He has published 757 research papers.  His major areas of research have been Tropical Diseases, Cardiovascular Diseases and Diarrhoeal Diseases. He has received 116 Awards, including 6 International and 110 National Awards. He has been honored with the prestigious Padma Bhushan Award by Her Excellency, the President of India on 26th January 2008 in the field of “Medicine”.

 

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