Hepatobiliary and Pancreatic Carcinogenesis in the Hamster

Editors: Tajima, Yoshitsugu, Kuroki, Tamotsu, Kanematsu, Takashi (Eds.)

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About this book

Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D.

Table of contents (14 chapters)

Table of contents (14 chapters)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-4-431-87773-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-4-431-87772-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-4-431-99859-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Hepatobiliary and Pancreatic Carcinogenesis in the Hamster
Editors
  • Yoshitsugu Tajima
  • Tamotsu Kuroki
  • Takashi Kanematsu
Copyright
2009
Publisher
Springer Japan
Copyright Holder
Springer-Verlag Tokyo
eBook ISBN
978-4-431-87773-8
DOI
10.1007/978-4-431-87773-8
Hardcover ISBN
978-4-431-87772-1
Softcover ISBN
978-4-431-99859-4
Edition Number
1
Number of Pages
XI, 241
Number of Illustrations
38 b/w illustrations, 59 illustrations in colour
Topics