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Major Histocompatibility Complex

Evolution, Structure, and Function

  • Conference proceedings
  • © 2000

Overview

Editors:
  1. Masanori Kasahara

    1. Department of Biosystems Science, School of Advanced Sciences, The Graduate University for Advanced Studies, Hayama, Japan
      CREST, Japan Science and Technology Corporation, Hayama, Japan

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  • Updated information on MHC genetics and evolution

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Table of contents (39 papers)

  1. Front Matter

    Pages ii-xxiii
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  2. Origin of the MHC

    1. Front Matter

      Pages 1-1
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    2. Jaws and AIS

      • Jan Klein, Akie Sato, Werner E. Mayer
      Pages 3-26

    3. The MHC paralogous group: listing of members and a brief overview

      • Masanori Kasahara, Makoto Yawata, Takashi Suzuki
      Pages 27-44

    4. The MHC « Big-Bang » : duplication and exon shuffling during chordate evolution. A hypothetico-deductive approach

      • Laurent Abi Rached, Pierre Pontarotti
      Pages 45-52

    5. Relationships among the genes encoding MHC molecules and the specific antigen receptors

      • Louis Du Pasquier
      Pages 53-65

    6. Conserved linkage among sea urchin homologs of genes encoded in the vertebrate MHC region

      • Jonathan P. Rast, Paola Oliveri, Eric H. Davidson
      Pages 66-74

  3. Genome organization of the MHC

    1. Front Matter

      Pages 75-75
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    2. Physical mapping of the class I regions of the rat major histocompatibility complex

      • Eberhard Günther, Sofia Ioannidu, Lutz Walter
      Pages 77-90

    3. MHC gene organization of the bony fish, medaka

      • Kiyoshi Naruse, Akihiro Shima, Masaru Nonaka
      Pages 91-109

    4. Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes

      • Andreas Ziegler, Anke Ehlers, Simon Forbes, John Trowsdale, Barbara Uchanska-Ziegler, Armin Volz et al.
      Pages 110-130

    5. Distribution of polypurine/polypyrimidine tract sequences in the human MHC region and their possible functions

      • Shigehiko Kanaya, Tatsuo Fukagawa, Asako Ando, Hidetoshi Inoko, Yoshihiro Kudo, Toshimichi Ikemura
      Pages 131-145

    6. Potential for paralogous mapping to simplify the genetics of diseases and functions associated with MHC haplotypes

      • Roger Dawkins, Jemma Berry, Patricia Martinez, Silvana Gaudieri, Jennie Hui, Sonia Cattley et al.
      Pages 146-157

    7. Transposable elements and the metamerismatic evolution of the HLA class I region

      • Jerzy K. Kulski, Silvana Gaudieri, Roger L. Dawkins
      Pages 158-177

    8. Polymorphism in the HLA class I region

      • Yoko Satta, Naoyuki Takahata
      Pages 178-185

    9. Nucleotide diversity within the human major histocompatibility complex: function of hitchhiking effect, duplications, indels and recombination

      • Silvana Gaudieri, Roger L. Dawkins, Kaori Habara, Jerzy K. Kulski, Takashi Gojobori
      Pages 186-200

  4. Function and evolutionary dynamics of MHC genes

    1. Front Matter

      Pages 201-201
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    2. Proteasomes and MHC class I-peptide generation

      • Keiji Tanaka, Nobuyuki Tanahashi, Naoki Shimbara
      Pages 203-212

    3. Comparative aspects of the MHC class I-related MR1, CD1D, and MIC genes in primates

      • Lutz Walter, Jung Won Seo, Eberhard Günther
      Pages 213-221

    4. Rat TL and CD1

      • Akihiro Matsuura, Miyuki Kinebuchi
      Pages 222-235
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Keywords

About this book

Every biological system is the outcome of evolution and has a history all its own. This history dictates how the system works and why it has certain properties and not others. This is why we need to study not only the structure and function, but also the history of the system. This argument undoubtedly applies to the study of the immune system and also to the study of the major histocompatibility complex (MHC). Since 1989, researchers of various scientific disciplines who share a deep inter­ est in MHC evolution have held a meeting every two years to discuss their latest research developments, exchange ideas, and foster friendship. Together with my colleagues Drs. Naoyuki Takahata and Yoko Satta, I organized the Sixth Interna­ tional Workshop on MHC Evolution in Hayama, Japan, May 25-29, 1999. This volume is the proceedings of that conference. It covers diverse topics pertinent to MHC evolution, including the origin of the adaptive immune system, the organi­ zation of the MHC in humans and other model vertebrates, MHC-parasite co­ evolution, and the nature and origin of MHC polymorphism. I hope that this book will be of interest not only for MHC researchers and immunologists, but also for other specialists who are interested in the evolution of biological systems in gen­ eral.

Editors and Affiliations

  • Department of Biosystems Science, School of Advanced Sciences, The Graduate University for Advanced Studies, Hayama, Japan

    Masanori Kasahara

  • CREST, Japan Science and Technology Corporation, Hayama, Japan

    Masanori Kasahara

Bibliographic Information

  • Book Title: Major Histocompatibility Complex

  • Book Subtitle: Evolution, Structure, and Function

  • Editors: Masanori Kasahara

  • DOI: https://doi.org/10.1007/978-4-431-65868-9

  • Publisher: Springer Tokyo

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Japan 2000

  • Hardcover ISBN: 978-4-431-70276-4Published: 01 February 2000

  • Softcover ISBN: 978-4-431-65870-2Published: 20 November 2013

  • eBook ISBN: 978-4-431-65868-9Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: XXIII, 561

  • Number of Illustrations: 86 b/w illustrations, 4 illustrations in colour

  • Topics: Immunology, Cell Biology, Molecular Medicine

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