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Advances in Osteoarthritis

Editors: Tanaka, Seisuke, Hamanishi, Chiaki (Eds.)

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  • ISBN 978-4-431-68497-8
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About this book

Basic research on osteoarthritis has been carried out mainly from the his­ tological and biochemical aspects of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical stress has been shown to be the principal factor in the initiation of osteoarthritis. Although the exact process by which mechanical stress leads to the total destruction of cartilage tissue remains unclear, several new research methods have enabled us to gain a deeper understanding of the process of degeneration. In October 1997, we organized an international symposium titled "Ad­ vances in Osteoarthritis" in Kobe, with the main topics being updated re­ search, diagnosis, and treatment of osteoarthritis. The proceedings of the symposium are presented here in five sections: (1) Mechanical stress and reactions of chondrocytes, such as intracellular ion changes, changes in the cytoskeleton, intracellular messenger systems, release of gas mediators, and changes in electromechanical properties of cartilage; (2) Functional diagnosis of osteoarthritis by MR imaging, and using calpain and collagenase III as new cartilage markers; (3) Treatment with a promising simple washout technique and IL-1RA and MMP antagonists; (4) Cartilage repair by new grafting tech­ niques; and (5) Problems following total joint replacement. We sincerely hope that the advanced knowledge provided in this volume of proceedings will be valuable to our readers.

Table of contents (21 chapters)

Table of contents (21 chapters)
  • Extracellular Ions and Hydrostatic Pressure: Their Influence on Chondrocyte Intracellular Ionic Composition

    Pages 3-20

    Urban, Jill P. G. (et al.)

  • Cytoskeleton and Proteoglycan Synthesis in Chondrocytes Under Hydrostatic Pressure

    Pages 21-34

    Parkkinen, Jyrki J. (et al.)

  • Cyclic Tensile Stretch Inhibits Proteoglycan Synthesis by Downregulating Protein Kinase C Activity

    Pages 35-47

    Fukuda, Kanji (et al.)

  • Muscarinic Receptor-Mediated Ca2+ Control, Protein Kinase C Activity, and Proteoglycan Release and Synthesis in Articular Chondrocytes

    Pages 48-55

    Hashima, Makoto (et al.)

  • Physical Diagnostics of Cartilage Degeneration

    Pages 59-73

    Treppo, Steven (et al.)

Buy this book

eBook $84.99
price for USA in USD
  • ISBN 978-4-431-68497-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $109.00
price for USA in USD
Softcover $109.00
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Advances in Osteoarthritis
Editors
  • Seisuke Tanaka
  • Chiaki Hamanishi
Copyright
1999
Publisher
Springer Japan
Copyright Holder
Springer-Verlag Tokyo
eBook ISBN
978-4-431-68497-8
DOI
10.1007/978-4-431-68497-8
Hardcover ISBN
978-4-431-70245-0
Softcover ISBN
978-4-431-68499-2
Edition Number
1
Number of Pages
X, 298
Topics

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