Molecular Pathology of Gastroenterological Cancer

Application to Clinical Practice

Editors: Tahara, Eiichi (Ed.)

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About this book

Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas­ ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo­ rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop­ me nt and progression of esophageal, gastric, and colon cancer require mul­ tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi­ tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi­ cal Association Clinical Laboratory since August 1993.

Table of contents (17 chapters)

  • Experimental Stomach Carcinogenesis

    Ohgaki, Hiroko (et al.)

    Pages 1-14

  • Multistep Carcinogenesis of Esophageal Carcinoma

    Nakamura, Yusuke (et al.)

    Pages 15-21

  • Oxidative Damage During the Gastric Precancerous Process

    Correa, Pelayo (et al.)

    Pages 23-29

  • Multiple Genetic Alterations and Abnormal Growth Factor Network in Human Esophageal Carcinomas

    Yoshida, Kazuhiro (et al.)

    Pages 31-41

  • Genetic Alterations in the Precursors of Gastric Cancer

    Ochiai, Atsushi (et al.)

    Pages 43-53

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-4-431-65915-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA in USD
  • ISBN 978-4-431-70195-8
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $79.99
price for USA in USD
  • ISBN 978-4-431-65917-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Pathology of Gastroenterological Cancer
Book Subtitle
Application to Clinical Practice
Editors
  • Eiichi Tahara
Copyright
1997
Publisher
Springer Japan
Copyright Holder
Springer Japan
eBook ISBN
978-4-431-65915-0
DOI
10.1007/978-4-431-65915-0
Hardcover ISBN
978-4-431-70195-8
Softcover ISBN
978-4-431-65917-4
Edition Number
1
Number of Pages
VIII, 267
Number of Illustrations and Tables
60 b/w illustrations, 8 illustrations in colour
Topics