Cardiac Adaptation and Failure

1. Front Matter

   Pages iii-xi

   PDF

2. Cardiac Adaptation to Coronary Insufficiency

   1. Front Matter

      Pages 1-1

      PDF

   2. Coronary Perfusion Pressure and Myocardial Metabolism

      1. Cardiac Contractility and Oxygen Consumption Under Altered Coronary Perfusion

         • Yoichi Goto

         Pages 3-19

      2. Effect of Coronary Perfusion on Myocardial Contractility in the Heart

         • Masafumi Kitakaze, Tetsuo Minamino, Toshikazu Morioka, Koichi Node, Michitoshi Inoue, Masatsugu Hori et al.

         Pages 21-35

   3. Coronary Blood Flow During Ischemia

      1. Coronary Flow Regulation Following Ischemia

         • Howard J. Zimring, Robert L. Engler

         Pages 37-45

      2. Coronary Collateral Growth in Canine Model with Gradual Coronary Stenosis and with Repetitive Coronary Occlusions

         • Hitonobu Tomoike

         Pages 47-54

   4. Ischemic and Reperfusion Injury

      1. Myocardial Ca2+ and Na+ Homeostasis and the Recovery of Postischemic Contractile Function

         • Martin M. Pike, Cameron S. Luo, Masafumi Kitakaze

         Pages 55-70

      2. Mechanism of Early Contractile Failure During Ischemia

         • Hideo Kusuoka, Yukihiro Koretsune, Mary C. Corretti, Eduardo Marban

         Pages 71-84

      3. Cellular Adaptation in Hibernating Myocardium in the Human

         • J. Ausma, F. Ramaekers, B. Shivalkar, F. Thone, W. Flameng, M. Borgers

         Pages 85-99

      4. Alterations in Membrane Phospholipids During Ischemia and Reperfusion

         • Ger J. van der Vusse, Marc van Bilsen, Robert S. Reneman

         Pages 101-117

      5. Reperfusion Injury in Patients with Acute Myocardial Infarction

         • Kazuhisa Kodama, Atsushi Hirayama

         Pages 119-130

   5. Cardioprotection from Ischemia and Reperfusion

      1. Beneficial Role of Interaction Between Alpha-Adrenoceptor Activity and Adenosine in Myocardial Ischemic and Reperfusion Injury

         • Masatsugu Hori, Masafumi Kitakaze, Toshimazu Morioka, Tetsuo Minamino, Seiji Takashima, Hiroshi Sato et al.

         Pages 131-146

      2. The Role of Adenosine in Ischemic Preconditioning

         • James M. Downey, Tetsuji Miura

         Pages 147-166

      3. Induction of Myocardial Manganese Superoxide Dismutase and Acquisition of Ischemic Tolerance

         • T. Kuzuya, S. Hoshida, M. Nishida, N. Yamashita, M. Hori, M. Tada

         Pages 167-173

3. Cardiac Adaptation to Mechanical Workload

   1. Front Matter

      Pages 175-175

      PDF

   2. Molecular Aspects

      1. Adaptation of the Left Ventricular Wall Under Pathological Circumstances

         • Robert S. Reneman, Theo Arts, Marc van Bilsen, Luc H. E. H. Snoeckx, Ger J. van der Vusse

         Pages 177-194

      2. Abnormalities in β-Adrenergic Signal Transduction with Myocardial Decompensation and Failure

         • Dorothy E. Vatner

         Pages 195-207

   3. Mechanical Aspects

      1. Effect of Mild Pressure Overload on Mechanoenergetics of the Rabbit Heart

         • Martin M. LeWinter, Hitoshi Yaku, Bryan K. Slinker

         Pages 209-222

      2. Mechanisms of Ventricular Reserve Limitation in Cardiac Hypertrophy

         • David A. Kass

         Pages 223-239

      3. Coronary Circulation in Patients with Pressure-Overloaded Left Ventricular Hypertrophy

         • Fumihiko Kajiya, Akihiro Kimura

         Pages 241-253

Advances in cellular physiology and molecular biology have now disclosed the metabolic changes and adaptational responses of the heart to various kinds of stresses. Topics covered in this volume include the regulation of myocardial proteins in mechanical overload, the alteration of adrenoceptors in the stressed heart, metabolic adaptation in cardiac hypertrophy, intracellular calcium metabolism in the ischemia-reperfused myocardium, calcium overload as a cause of myocardial stunning, acquisition of ischemic tolerance by ischemic preconditioning, factors that accelerate myocardial injury, and ventricular remodeling in the ischemic heart. As an update of the latest findings in basic cardiology, this book will benefit both researchers and clinical practitioners.

• Cardiac Hypertrophy
• Heart Failure
• Ischemic and Reperfusion Injury
• adaptation
• biology
• heart
• metabolism
• physiology
• regulation

• Division of Cardiology, The First Department of Medicine, Osaka University School of Medicine, Suita, Osaka, 565, Japan

  Masatsugu Hori

• The First Department of Internal Medicine, Fukushima Medical College, Fukushima, Japan

  Yukio Maruyama

• Department of Physiology, University of Limburg, Maastricht, The Netherlands

  Robert S. Reneman

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