The LEC Rat

A New Model for Hepatitis and Liver Cancer

Editors: Mori, M., Yoshida, M.C., Takeichi, N., Taniguchi, N. (Eds.)

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About this book

The LEC strain of rats, which spontaneously develop acute hepatitis as­ sociated with jaundice, chronic hepatitis, and ultimately hepatocellular carcinomas, was established by scientists in Sapporo, Japan. Careful ob­ servation and breeding led to the initial discovery of this characteristic, inherited liver disease in rats. Subsequent collaboration between scientists in Sapporo and other centers has revealed an autosomal recessive nature of inheritance, along with a variety of histopathological and biochemical findings. The causative mechanism(s) underlying this abnormality remained a mystery for some time, providing a challenge for many scientists who were attracted to the quest for clues to this enigma. In particular, the mech­ anism of spontaneous development of hepatocellular carcinomas in rats overcoming the acute phase of hepatitis and surviving with chronic hepatitis proved extremely interesting, because the involvement of a causative virus had been excluded in the early stages of investigation. Professor Michio Mori of Sapporo Medical College played a key role in the study of LEC rats, especially in the elucidation of the pathogenesis of hepatitis and hepatocellular carcinoma. He is one of the editors of this monograph which is composed of original contributions by the many scientists who have carried out their own studies on LEC rats. Of the various histopathological and biochemical alterations which have been reported, some are clearly secondary or tertiary events sequential to the primary change caused by gene mutation.

Table of contents (37 chapters)

  • Origin of the LEC Strain with a New Mutation Causing Hereditary Hepatitis

    Yoshida, Michihiro C. (et al.)

    Pages 3-10

  • Reproductive Performance and Effects of Pregnancy on the Acute Phase of Hepatitis in LEC Rats

    Kasai, Noriyuki (et al.)

    Pages 11-19

  • Differences in the Course of Hereditary Hepatitis Between Males and Females, and Between Virgins and Parous Female LEC Rats

    Yamazaki, Kazuto (et al.)

    Pages 20-29

  • Pathological and Laboratory Findings of “LEC/Otk” Rats Maintained Under SPF Conditions

    Kawano, Kazuya (et al.)

    Pages 30-40

  • Clinical and Pathological Characteristics of LEC Rats with Spontaneous Hepatitis

    Namieno, Tsutomu (et al.)

    Pages 41-53

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-4-431-68153-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-4-431-68155-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The LEC Rat
Book Subtitle
A New Model for Hepatitis and Liver Cancer
Editors
  • Michio Mori
  • Michihiro C. Yoshida
  • Noritoshi Takeichi
  • Naoyuki Taniguchi
Copyright
1991
Publisher
Springer Japan
Copyright Holder
Springer-Verlag Tokyo
eBook ISBN
978-4-431-68153-3
DOI
10.1007/978-4-431-68153-3
Softcover ISBN
978-4-431-68155-7
Edition Number
1
Number of Pages
XVI, 356
Topics