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Evolution of the Human Genome I

The Genome and Genes

  • Book
  • © 2017

Overview

Editors:
  1. Naruya Saitou

    1. Division of Population Genetics, National Institute of Genetics, Mishima, Japan

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  • Provides a bird’s-eye view of the human genome
  • Presents evolutionary perspectives on the human genome
  • Offers interesting topics such as rubbish DNA, opsin genes, transcription factors, and gut metagenomes

Part of the book series: Evolutionary Studies (EVOLUS)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-viii
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  2. Overview of the Human Genome

    1. Front Matter

      Pages 1-1
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    2. Human Evolution and Human Genome at a Glance

      • Naruya Saitou
      Pages 3-17

    3. Rubbish DNA: The Functionless Fraction of the Human Genome

      • Dan Graur
      Pages 19-60

    4. GC Content Heterogeneity

      • Satoshi Oota
      Pages 61-92

    5. Protein-Coding and Noncoding RNA Genes

      • Tadashi Imanishi
      Pages 93-116

    6. Duplicated Genes

      • Takashi Kitano
      Pages 117-130

    7. Recombination

      • Ludovica Montanucci, Jaume Bertranpetit
      Pages 131-142

    8. CNVs and Microsatellite DNA Polymorphism

      • Naoko Takezaki
      Pages 143-155

  3. The Human Genome Viewed Through Genes

    1. Front Matter

      Pages 157-157
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    2. Genes on X and Y Chromosomes

      • Yoko Satta, Yukako Katsura, Mineyo Iwase
      Pages 159-172

    3. Human Leukocyte Antigen (HLA) Region in Human Population Studies

      • Timothy A. Jinam
      Pages 173-179

    4. Evolution of Genes for Color Vision and the Chemical Senses in Primates

      • Shoji Kawamura, Amanda D. Melin
      Pages 181-216

    5. Global Landscapes of Human Phenotypic Variation in Inherited Traits

      • Ryosuke Kimura
      Pages 217-239

    6. Transcription Factor Genes

      • Mahoko Ueda Takahashi, So Nakagawa
      Pages 241-263

    7. Genetics of Diabetes: Are They Thrifty Genotype?

      • Ituro Inoue, Hirofumi Nakaoka
      Pages 265-272

    8. Disease-Related Genes from Population Genetic Aspect and Their Functional Significance

      • Ituro Inoue, Hirofumi Nakaoka
      Pages 273-283

    9. Microbe Genomes Associated with Human Body

      • Chaochun Wei, Ben Jia
      Pages 285-300

  4. Back Matter

    Pages 301-305
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Keywords

About this book

This book reviews the human genome from an evolutionary perspective. No such book has ever been published before, although there are many books on human genomes. There are two parts in this book: Overview of the Human Genome (Part I) and The Human Genome Viewed through Genes (Part II). In Part I, after a brief review of human evolution and the human genome (by Naruya Saitou), chapters on rubbish or junk DNA (by Dan Graur), GC content heterogeneity (by Satoshi Oota), protein coding and RNA coding genes (by Tadashi Imanishi), duplicated genes (by Takashi Kitano), recombinations (by Montanucci and Bertranpetit), and copy number variations including microsatellites (by Naoko Takezaki) are discussed. Readers can obtain various new insights on the human genome from this part. In Part II, genes in X and Y chromosomes (by Yoko Satta and others), HLA genes (by Timothy A. Jinam), opsin genes (by Shoji Kawamura and Amanda D. Melin), genes related to phenotypic variations (by RyosukeKimura), transcription factors (by Mahoko Takahashi and So Nakagawa), diabetes-related genes (by Ituro Inoue), disease genes in general (by Ituro Inoue and Hirofumi Nakaoka), and microbial genomes (by Chaochun Wei) are discussed. The human genome sequences were determined in 2004, and after more than 10 years we are now beginning to understand the human genome from an evolutionary point of view. This book furnishes readers with a good summary of current research in the field.

Reviews

“Saitou’s Evolution of the Human Genome I offers a strikingly comprehensive introduction to both the evolutionary history of the human genome and molecular and computational methods for studying it. … it will serve as useful background reading for advanced undergraduates and beginning graduate students venturing for the first time into this fast-moving field. Summing Up: Recommended.” (D. P. Genereux, Choice, Vol. 56 (2), October, 2018)

Editors and Affiliations

  • Division of Population Genetics, National Institute of Genetics, Mishima, Japan

    Naruya Saitou

About the editor

Naruya Saitou, National Institute of Genetics, Mishima, Japan

Bibliographic Information

  • Book Title: Evolution of the Human Genome I

  • Book Subtitle: The Genome and Genes

  • Editors: Naruya Saitou

  • Series Title: Evolutionary Studies

  • DOI: https://doi.org/10.1007/978-4-431-56603-8

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Japan KK 2017

  • Hardcover ISBN: 978-4-431-56601-4Published: 22 February 2018

  • Softcover ISBN: 978-4-431-56831-5Published: 07 June 2019

  • eBook ISBN: 978-4-431-56603-8Published: 08 February 2018

  • Series ISSN: 2509-484X

  • Series E-ISSN: 2509-4858

  • Edition Number: 1

  • Number of Pages: VIII, 305

  • Number of Illustrations: 35 b/w illustrations, 39 illustrations in colour

  • Topics: Evolutionary Biology, Human Genetics, Anthropology

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