Advances in Experimental Medicine and Biology

Drebrin

From Structure and Function to Physiological and Pathological Roles

Editors: Shirao, Tomoaki, Sekino, Yuko (Eds.)

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  • Offers the first comprehensive review of drebrin from its molecular structure and function to the physiological and pathological roles edited by the discoverer of drebrin
  • Presents a multidisciplinary review of drebrin including that of neuroscience, cancer science, immunology, and cell biology in various tissues
  • Provides the most up-to-date knowledge and intriguing hypotheses related to drebrin and drebrin-decorated F-actin by authoritative original authors of key papers
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eBook $169.00
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  • ISBN 978-4-431-56550-5
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Hardcover $219.99
price for USA in USD
  • ISBN 978-4-431-56548-2
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  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $219.99
price for USA in USD
  • ISBN 978-4-431-56817-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

This book is the first comprehensive review of drebrin, which plays pivotal roles in various cellular events, via forming unique actin cytoskeletons, including synapse formation and in synaptic function. Particularly the loss of drebrin from dendritic spines is used as a marker of dementia in neurological disorders such as Alzheimer’s disease. Since drebrin was first identified by our group in 1985, many studies of drebrin have been done in various fields, including not only molecular biology, biophysics, cell biology, neuroscience, clinical studies, spermatogenesis, immunology, and cancer metastasis, but others as well. The structure of this book facilitates the understanding of the whole picture of studies on drebrin. The volume begins with a general introduction to drebrin, and then the chapters in the second part provide the basic knowledge for further understanding. The third part examines its function in the nervous system, and the fourth part discusses its function in the non-nervous system. This work will appeal to researchers who are interested in cytoskeletal dynamics at membrane-cytoskeletal interface as well as the number of them who use drebrin as a tool, such as a marker of synaptic function or a disease marker. This volume is kept as concise as possible in order to be understood by readers in diverse scientific disciplines.

About the authors

Tomoaki Shirao, MD, PhD
Department of Neurobiology and Behavior
Gunma University Graduate School of MedicineGunma, Japan

Yuko Sekino, PhD
Division of Pharmacology
National Institute of Health SciencesTokyo, Japan

Table of contents (24 chapters)

Table of contents (24 chapters)
  • General Introduction to Drebrin

    Pages 3-22

    Shirao, Tomoaki (et al.)

  • Molecular Cloning of Drebrin: Progress and Perspectives

    Pages 25-36

    Kojima, Nobuhiko

  • Biochemistry of Drebrin and Its Binding to Actin Filaments

    Pages 37-47

    Ishikawa, Ryoki

  • Phosphorylation of Drebrin and Its Role in Neuritogenesis

    Pages 49-60

    Gordon-Weeks, Phillip R.

  • Remodeling of Actin Filaments by Drebrin A and Its Implications

    Pages 61-82

    Grintsevich, Elena E.

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-4-431-56550-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-4-431-56548-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $219.99
price for USA in USD
  • ISBN 978-4-431-56817-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Drebrin
Book Subtitle
From Structure and Function to Physiological and Pathological Roles
Editors
  • Tomoaki Shirao
  • Yuko Sekino
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1006
Copyright
2017
Publisher
Springer Japan
Copyright Holder
Springer Japan KK
eBook ISBN
978-4-431-56550-5
DOI
10.1007/978-4-431-56550-5
Hardcover ISBN
978-4-431-56548-2
Softcover ISBN
978-4-431-56817-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 401
Number of Illustrations
29 b/w illustrations, 82 illustrations in colour
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