Pathogenesis of Idiopathic Scoliosis

1. Front Matter

   Pages i-ix

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2. Definition of Adolescent Idiopathic Scoliosis

   • Jean Dubousset

   Pages 1-25

3. Adolescent Idiopathic Scoliosis: Natural History

   • Cameron B. Barton, Stuart L. Weinstein

   Pages 27-50

4. The Genetic Architecture of Adolescent Idiopathic Scoliosis

   • Anas M. Khanshour, Carol A. Wise

   Pages 51-74

5. Biomechanics of Adolescent Idiopathic Scoliosis

   • Wafa Skalli, Claudio Vergari

   Pages 75-97

6. Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers

   • Dina Nada, Alain Moreau

   Pages 99-124

7. Bone Metabolism in AIS

   • Jack C. Y. Cheng, Wayne Y. W. Lee, Elisa M. S. Tam, T. P. Lam

   Pages 125-155

8. Neurological Research in Idiopathic Scoliosis

   • Masafumi Machida

   Pages 157-188

This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS.

• Idiopathic Scoliosis
• Pathogenesis Study
• Spinal Deformity
• Central nervous system
• Genetics research

• Department of Spine and Spinal Cord Surgery, Yokohama Brain and Spine Center, Yokohama, Japan

  Masafumi Machida

• University of Iowa, Iowa, USA

  Stuart L. Weinstein

• Academie Nationale de Medecine, Paris, France

  Jean Dubousset

Masafumi Machida, M.D.: Director of National Institute of Musculo-Skeletal Disorders

Stuart L. Weinstein,M.D.:
Ignacio V. Ponseti Chair of Ortopaedic Surgery, Department of Orthopaedic Surgery University of Iowa Health Cara


Jean Dubousset,M.D.: 
Academie Nationale de Medecine

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