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Pathogenesis of Idiopathic Scoliosis

  • Book
  • © 2018

Overview

Editors:
  1. Masafumi Machida

    1. Department of Spine and Spinal Cord Surgery, Yokohama Brain and Spine Center, Yokohama, Japan

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  2. Stuart L. Weinstein

    1. University of Iowa, Iowa, USA

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  3. Jean Dubousset

    1. Academie Nationale de Medecine, Paris, France

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  • Presents the most current clinical and experimental topics in idiopathic scoliosis (IS)

  • Describes the variety of fields in which research into IS is being carried out

  • Provides useful insights into IS from leading specialists around the world

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Definition of Adolescent Idiopathic Scoliosis

    • Jean Dubousset
    Pages 1-25

  3. Adolescent Idiopathic Scoliosis: Natural History

    • Cameron B. Barton, Stuart L. Weinstein
    Pages 27-50

  4. The Genetic Architecture of Adolescent Idiopathic Scoliosis

    • Anas M. Khanshour, Carol A. Wise
    Pages 51-74

  5. Biomechanics of Adolescent Idiopathic Scoliosis

    • Wafa Skalli, Claudio Vergari
    Pages 75-97

  6. Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers

    • Dina Nada, Alain Moreau
    Pages 99-124

  7. Bone Metabolism in AIS

    • Jack C. Y. Cheng, Wayne Y. W. Lee, Elisa M. S. Tam, T. P. Lam
    Pages 125-155

  8. Neurological Research in Idiopathic Scoliosis

    • Masafumi Machida
    Pages 157-188
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Keywords

About this book

This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS.

Editors and Affiliations

  • Department of Spine and Spinal Cord Surgery, Yokohama Brain and Spine Center, Yokohama, Japan

    Masafumi Machida

  • University of Iowa, Iowa, USA

    Stuart L. Weinstein

  • Academie Nationale de Medecine, Paris, France

    Jean Dubousset

About the editors

Masafumi Machida, M.D.: Director of National Institute of Musculo-Skeletal Disorders

Stuart L. Weinstein,M.D.:
Ignacio V. Ponseti Chair of Ortopaedic Surgery, Department of Orthopaedic Surgery University of Iowa Health Cara


Jean Dubousset,M.D.: 
Academie Nationale de Medecine

Bibliographic Information

  • Book Title: Pathogenesis of Idiopathic Scoliosis

  • Editors: Masafumi Machida, Stuart L. Weinstein, Jean Dubousset

  • DOI: https://doi.org/10.1007/978-4-431-56541-3

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Japan KK 2018

  • Hardcover ISBN: 978-4-431-56539-0Published: 15 March 2018

  • Softcover ISBN: 978-4-431-56861-2Published: 15 January 2019

  • eBook ISBN: 978-4-431-56541-3Published: 23 February 2018

  • Edition Number: 1

  • Number of Pages: IX, 188

  • Number of Illustrations: 17 b/w illustrations, 21 illustrations in colour

  • Topics: Orthopedics, Pathology, Neurology

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