Osteosarcoma

1. Front Matter

   Pages i-xi

   PDF

2. Basic Research and Experimental Therapy

   1. Front Matter

      Pages 1-1

      PDF

   2. Genetics of Osteosarcoma

      • Junya Toguchida

      Pages 3-17

   3. Basic Research for Osteosarcoma Lung Metastasis (LM8)

      • Kazuyuki Itoh

      Pages 19-29

   4. Immunotherapy for Osteosarcoma

      • Tomohide Tsukahara, Takuro Wada

      Pages 31-41

3. Clinical Features

   1. Front Matter

      Pages 43-43

      PDF

   2. Outcome of Treatment for Osteosarcoma of the Extremities Over the Last 20 Years: Report from 11 Referral Centers in Japan

      • Koichi Ogura, Hiroaki Hiraga, Takeshi Ishii, Toshifumi Ozaki, Yoshihiro Nishida, Hideo Morioka et al.

      Pages 45-57

   3. Osteosarcoma in the Elderly: Clinical Features and Outcome

      • Yoshihiro Nishida

      Pages 59-71

   4. Prognostic Factors for Osteosarcoma Patients

      • Mitsunori Kaya

      Pages 73-79

4. Chemotherapy

   1. Front Matter

      Pages 81-81

      PDF

   2. Neoadjuvant Chemotherapy Developed in Japan

      • Hiroaki Hiraga

      Pages 83-96

   3. Neoadjuvant Chemotherapy: Osaka University Osteosarcoma (OOS) Regimen

      • Shigeki Kakunaga, Takafumi Ueda, Norifumi Naka, Shigeyuki Kuratsu, Nobuhito Araki, Yasuaki Aoki et al.

      Pages 97-106

5. Surgery

   1. Front Matter

      Pages 107-107

      PDF

   2. Endoprosthetic Reconstruction for Extremity Osteosarcoma

      • Akihiko Matsumine

      Pages 109-124

   3. Limb-Salvage Surgery and Reconstruction for Skeletally Immature Childhood Osteosarcoma: Extendible Endoprosthesis

      • Hiroyuki Futani, Shinichi Yoshiya

      Pages 125-133

   4. Limb Salvage Surgery for Pelvic Osteosarcoma

      • Toshiyuki Kunisada, Ken Takeda, Tomohiro Fujiwara, Shinsuke Sugihara, Toshifumi Ozaki

      Pages 135-147

   5. Management of Postoperative Infection After Limb Salvage Surgery in Osteosarcoma Patients

      • Takeshi Morii

      Pages 149-167

6. Surgery: Biological Reconstruction

   1. Front Matter

      Pages 169-169

      PDF

   2. Biological Reconstruction for Extremity Osteosarcoma: Long-Term Results and Current Concept of Intraoperative Extracorporeal Irradiated Bone Graft (IORBG)

      • Nobuhito Araki, Osaka Orthopaedic Oncology Group

      Pages 171-182

   3. Biological Reconstruction for Extremity Osteosarcoma: Pasteurized Autogenous Bone Graft

      • Keisuke Ae

      Pages 183-200

This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10–15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis fromosteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine and pelvis. In this volume the author provides valuable descriptions of an important new treatment modality for a multidisciplinary approach for osteosarcoma patients.

• doxorubicin
• ifosfamide
• limb-salvage surgery
• methotrexate
• neoadjuvant chemotherapy
• pulmonary metastasis
• surgical oncology
• Radiaton Oncology

“This book describes the multidisciplinary treatment of osteosarcoma as practiced in Japan. … This will most likely be of value to trainees in oncology -- medical, radiation, and surgical -- as well as practitioners in the field. … This is a worthwhile contribution. It is a niche monograph that will be of interest to those in the field who want an update on the techniques and approaches used in Japan.” (Carol Scott-Conner, Doody's Book Reviews, June, 2016)

• Osaka National Hospital, Osaka University, Osaka, Japan

  Takafumi Ueda

• National Cancer Center Hospital, Tokyo, Japan

  Akira Kawai

Takafumi Ueda, Osaka National Hospital, Orthopaedic Oncology Group, Department of Orthopaedic Surgery


Akira Kawai, National Cancer Center Hospital, Division of Musculoskeletal Oncology

Policies and ethics