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Anesthesia and Neurotoxicity

  • Book
  • © 2017

Overview

Editors:
  1. Yuji Morimoto

    1. Graduate School of Medicine, Hokkaido University Graduate, School of Medicine, Sapporo, Japan

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  • Describes current topics of neurotoxicity of anesthesia

  • Suggests a strategy for the prevention and treatment of perioperative neurotoxicity

  • Contains valuable contributions from well-known professionals

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
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  2. Neurotoxicity of the Anesthetics for Developing Brain

    1. Front Matter

      Pages 1-1
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    2. Laboratory Findings: To What Degree Can We Extrapolate the Animal Data to the Bedside?

      • Yuji Morimoto, Yosuke Uchida, Hitoshi Saito
      Pages 3-15

    3. Clinical Findings Including Prevention and Treatment

      • Yasushi Satoh
      Pages 17-31

    4. Implications for Pediatric Anesthesia

      • Koichi Yuki, Yasushi Mio, Shoichi Uezono
      Pages 33-48

  3. Postoperative Delirium and Cognitive Dysfunction

    1. Front Matter

      Pages 49-49
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    2. Present Clinical Status of Postoperative Delirium (POD)

      • Moritoki Egi
      Pages 51-58

    3. Present Clinical Status of Postoperative Cognitive Dysfunction in Cardiovascular Surgery

      • Kazuyoshi Ishida, Atsuo Yamashita, Satoshi Yamashita, Mishiya Matsumoto
      Pages 59-94

    4. Present Clinical Status of Postoperative Cognitive Dysfunction Following Noncardiac Surgery

      • Tatsuo Horiuchi, Tomonori Takazawa, Shigeru Saito
      Pages 95-103

    5. Diagnosis of POD and POCD

      • Shigehito Sawamura
      Pages 105-120

    6. Prevention and Treatment of Postoperative Delirium and Postoperative Cognitive Dysfunction

      • Mitsuru Ida, Masahiko Kawaguchi
      Pages 121-132

    7. Mechanisms of POD and POCD: Effects of Anesthetics

      • Tomoyuki Miyazaki, Yoshikazu Yamaguchi, Takahisa Goto
      Pages 133-150

    8. Mechanism of POD and POCD - Effect of Other Than Anesthetics

      • Shusuke Sekine, Hiroyuki Uchino
      Pages 151-167
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Keywords

About this book

This book, written by leading Japanese experts in the field, describes the latest findings on the neurotoxicity of anesthetics for the developing brain, postoperative delirium and cognitive dysfunction.

It describes the risk factors for postoperative cognitive dysfunction in elderly surgical patients. Since the number of elderly patients undergoing surgery and anesthesia continues to increase, it is important to improve our understanding of the risks and mechanisms of postoperative delirium and cognitive dysfunction, potential ways to prevent or alleviate them and the public health implications.

Recently, it has been shown that using anesthetics on the developing brain causes apoptotic neurodegeneration and persistent learning/memory deficits later in life. Anesthesiologists need more information on this mechanism in the human brain.

The negative effects of anesthesia and surgery on the nervous system have attracted attention lately; this book provides physicians, researchers, and postdocs with invaluable information on this topic.

Reviews

“Anesthesia and Neurotoxicity – a unique synthesis of basic science and clinical research – is concerned with the neurotoxic effects of anesthetic drugs. It is a concise, up-to-date review of the literature and could be a useful reference for anesthesia care providers who may have to allay their patients’ concerns about the potential harmful effects of general anesthesia.” (O. Predescu, Canadian Journal of Anesthesia/Journal canadien d'anesthésie, Vol. 65 (10), October, 2018)


“This book covers a wide range of anesthesia and neurotoxicity topics: from developmental neurotoxicity to POD and POCD, from animal studies to clinical evidence, from diagnosis of neurotoxicity to prevention and treatment approaches, and from symptoms to the underlying mechanisms.” (Xiaowen Bai, Anesthesia & Analgesia, Vol. 127 (2), August, 2018)

Editors and Affiliations

  • Graduate School of Medicine, Hokkaido University Graduate, School of Medicine, Sapporo, Japan

    Yuji Morimoto

About the editor

Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine.

Bibliographic Information

  • Book Title: Anesthesia and Neurotoxicity

  • Editors: Yuji Morimoto

  • DOI: https://doi.org/10.1007/978-4-431-55624-4

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Japan 2017

  • Hardcover ISBN: 978-4-431-55623-7Published: 15 June 2017

  • Softcover ISBN: 978-4-431-56670-0Published: 15 August 2018

  • eBook ISBN: 978-4-431-55624-4Published: 30 May 2017

  • Edition Number: 1

  • Number of Pages: VIII, 167

  • Number of Illustrations: 4 b/w illustrations, 11 illustrations in colour

  • Topics: Anesthesiology, Neurology, Pharmacology/Toxicology

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