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JSS Research Series in Statistics

Dose-Finding Designs for Early-Phase Cancer Clinical Trials

A Brief Guidebook to Theory and Practice

Authors: Daimon, Takashi, Hirakawa, Akihiro, Matsui, Shigeyuki

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  • Serves as an excellent resource in the design and analysis of early phase dose-finding trials
  • Covers a wide range of various methods for designing early phase dose-finding clinical trials in oncology and other areas
  • Provides an overview of complex designs for researchers in biostatistics and statistical science
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eBook $44.99
price for USA in USD (gross)
  • ISBN 978-4-431-55585-8
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  • Immediate eBook download after purchase
Softcover $59.99
price for USA in USD
  • ISBN 978-4-431-55584-1
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  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
About this book

This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.

About the authors

Takashi Daimon, Department of Biostatistics, Hyogo College of MedicineAkihiro Hirakawa, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of MedicineShigeyuki Matsui, Department of Biostatistics, Nagoya University Graduate School of Medicine

Reviews

“The book under review is intended to serve as a brief handbook for graduate students and biostatistics, as well as for oncologists who are involved in the analysis of methods for developing optimal doses for treating cancer in the early stages.” (Fatima T. Adylova, zbMATH 1427.92001, 2020)

Table of contents (6 chapters)

Table of contents (6 chapters)

Buy this book

eBook $44.99
price for USA in USD (gross)
  • ISBN 978-4-431-55585-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $59.99
price for USA in USD
  • ISBN 978-4-431-55584-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Dose-Finding Designs for Early-Phase Cancer Clinical Trials
Book Subtitle
A Brief Guidebook to Theory and Practice
Authors
Series Title
JSS Research Series in Statistics
Copyright
2019
Publisher
Springer Japan
Copyright Holder
The Author(s), under exclusive licence to Springer Japan KK
Distribution Rights
Distribution rights worldwide
eBook ISBN
978-4-431-55585-8
DOI
10.1007/978-4-431-55585-8
Softcover ISBN
978-4-431-55584-1
Series ISSN
2364-0057
Edition Number
1
Number of Pages
XV, 133
Number of Illustrations
4 b/w illustrations, 3 illustrations in colour
Topics

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