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Immunotherapy of Cancer

An Innovative Treatment Comes of Age

  • Book
  • © 2016

Overview

Editors:
  1. Yoshiyuki Yamaguchi

    1. Department of Clinical Oncology, Kawasaki Medical School, Okayama, Japan

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  • Summarizes the rationale, present status, and future perspective for cancer immunotherapy

  • Provides comprehensive knowledge of the mechanism of cancer immunotherapy

  • Enriches the reader’s understanding of personalized clinical application of cancer immunotherapy

  • Includes supplementary material: sn.pub/extras

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-ix
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  2. Overview, History, Classification

    1. Front Matter

      Pages 1-1
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    2. Overview of Current Cancer Immunotherapy

      • Yoshiyuki Yamaguchi
      Pages 3-17

  3. BRMs and Crude Agents

    1. Front Matter

      Pages 19-19
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    2. Bacterial Preparations

      • Junichi Sakamoto, Michitaka Honda, Toru Aoyama
      Pages 21-35

    3. Polysaccharides

      • Yasuyuki Sugiyama
      Pages 37-50

    4. BCG

      • Yoichi Mizutani
      Pages 51-59

  4. Adoptive Cell Therapy

    1. Front Matter

      Pages 61-61
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    2. αβ-T Cells

      • Atsushi Aruga
      Pages 63-73

    3. NKT Cell-Based Immunotherapy

      • Shinichiro Motohashi
      Pages 75-86

    4. Natural Killer Cells

      • Satoshi Kokura
      Pages 87-98

    5. γδ T Cell-Based Cancer Immunotherapy

      • Hirokazu Matsushita, Kazuhiro Kakimi
      Pages 99-119

    6. Genetically Engineered T Cells

      • Hiroaki Ikeda
      Pages 121-132

  5. Vaccine Therapy

    1. Front Matter

      Pages 133-133
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    2. Peptide Vaccine

      • Koji Kono
      Pages 135-142

    3. Personalized Peptide Vaccine

      • Masanori Noguchi
      Pages 143-158

    4. WT1 Peptide Vaccine for the Treatment of Malignancies: Its Development, Recent Progress, and Future Perspectives

      • Yoshihiro Oka, Akihiro Tsuboi, Hiroko Nakajima, Fumihiro Fujiki, Sumiyuki Nishida, Soyoko Morimoto et al.
      Pages 159-185

    5. Protein Vaccine

      • Shinichi Kageyama
      Pages 187-196

    6. Dendritic Cell-Based Vaccine for Cancer

      • Masato Okamoto
      Pages 197-220

  6. Immunoadjuvants

    1. Front Matter

      Pages 221-221
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Keywords

About this book

This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted.

 With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival. 

Reviews

“This book covers the history, current status and future of cancer immunotherapy. … The content of the book is simply exiting, well written and fully covering the problem. I strongly recommend this book to everybody working in the field.” (Jan Lakota, Neoplasma, Vol. 64 (1), 2017)

Editors and Affiliations

  • Department of Clinical Oncology, Kawasaki Medical School, Okayama, Japan

    Yoshiyuki Yamaguchi

About the editor

Dr. Yoshiyuki Yamaguchi, MD, PhD, Professor, Department of Clinical Oncology, Kawasaki Medical School, Kurashiki, Japan  

Bibliographic Information

  • Book Title: Immunotherapy of Cancer

  • Book Subtitle: An Innovative Treatment Comes of Age

  • Editors: Yoshiyuki Yamaguchi

  • DOI: https://doi.org/10.1007/978-4-431-55031-0

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Japan 2016

  • Hardcover ISBN: 978-4-431-55030-3Published: 04 March 2016

  • Softcover ISBN: 978-4-431-56639-7Published: 07 April 2018

  • eBook ISBN: 978-4-431-55031-0Published: 22 February 2016

  • Edition Number: 1

  • Number of Pages: IX, 358

  • Number of Illustrations: 8 b/w illustrations, 38 illustrations in colour

  • Topics: Oncology, Cancer Research, Immunology

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