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Fifty Years of Cytochrome P450 Research

Editors: Yamazaki, Hiroshi (Ed.)

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  • Covers the 50-year research history of P450 from its discovery to the most up-to-date progress
  • Provides a comprehensive overview of P450 research across many fields, including molecular biology, biotechnology, pharmacology and medicine
  • Includes figures and tables that facilitate understanding for young scientists interested in P450 research
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eBook $129.00
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  • ISBN 978-4-431-54992-5
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Softcover $169.99
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About this book

This book encompasses major progress and future directions in cytochrome P450 (P450) research. Included are contributions by pioneers in the discovery of P450, with chapters on the molecular and functional properties of P450 and cutting-edge applications knowledge from various fields. P450 research has its roots in metabolism, but the true beginning was in 1962 with the publication by Tsuneo Omura and Ryo Sato in The Journal of Biological Chemistry on their discovery of the cytochrome. Following this groundbreaking study, over the last half-century, research has revealed that many forms of P450 exist in animals, plants and microorganisms. P450 research has expanded into many different fields including medicine, agriculture and biotechnology and has drawn the attention of industries for its bioengineering applications, such as drug development and creation of the “blue rose”. Also, research on nuclear receptors, which has grown out of research on the regulatory mechanisms of P450 genes, has become an important area in biology, medical science, pharmacology and clinical medicine—for example, with recent developments in personalized medicines. This book will draw readers into the important and exciting world of P450 and will encourage young students and scientists in P450 research to continue expanding the field via new approaches.

Table of contents (21 chapters)

Table of contents (21 chapters)
  • Pioneers in the Early Years of Cytochrome P450 Research

    Pages 3-16

    Omura, Tsuneo

  • Fifty Years of Progress in Drug Metabolism and Toxicology: What Do We Still Need to Know About Cytochrome P450 Enzymes?

    Pages 17-41

    Guengerich, F. Peter

  • Fifty Years of Cytochrome P450 Research: Examples of What We Know and Do Not Know

    Pages 43-71

    Lamb, David C. (et al.)

  • Cytochrome P450 Dynamics

    Pages 75-94

    Poulos, Thomas L.

  • Structural and Functional Diversity of Cytochrome P450

    Pages 95-106

    Nagano, Shingo

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-4-431-54992-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-4-431-54991-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-4-431-56176-7
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Fifty Years of Cytochrome P450 Research
Editors
  • Hiroshi Yamazaki
Copyright
2014
Publisher
Springer Japan
Copyright Holder
Springer Japan
eBook ISBN
978-4-431-54992-5
DOI
10.1007/978-4-431-54992-5
Hardcover ISBN
978-4-431-54991-8
Softcover ISBN
978-4-431-56176-7
Edition Number
1
Number of Pages
IX, 409
Number of Illustrations
50 b/w illustrations, 51 illustrations in colour
Topics

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