OPLL

1. Front Matter

   Pages I-XVIII

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. History of Research

      • Kozo Nakamura

      Pages 3-4

3. Epidemiology

   1. Front Matter

      Pages 5-5

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   2. Overview of Epidemiology and Genetics

      • Shunji Matsunaga, Takashi Sakou

      Pages 7-9

   3. OPLL: Disease Entity, Incidence, Literature Search, and Prognosis

      • Shunji Matsunaga, Takashi Sakou

      Pages 11-17

   4. Genetic Susceptibility to OPLL

      • Ituro Inoue

      Pages 19-25

4. Pathology and Pathogenesis

   1. Front Matter

      Pages 27-27

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   2. Overview of Etiology and Pathogenesis

      • Toshihiko Taguchi

      Pages 29-31

   3. Etiology and Pathogenesis

      • Toshihiko Taguchi

      Pages 33-35

   4. Contribution of Metabolic Conditions to Ossification of the Posterior Longitudinal Ligament of the Spine

      • Hiroshi Kawaguchi, Toru Akune, Naoshi Ogata, Atsushi Seichi, Katsushi Takeshita, Kozo Nakamura

      Pages 37-40

   5. Review of Histopathological Studies on OPLL of the Cervical Spine, with Insights into the Mechanism

      • Nobuyuki Tsuzuki

      Pages 41-47

   6. Pathology of Ossification of the Ligamentum Flavum

      • Munehito Yoshida

      Pages 49-57

   7. Possible Roles of Bone Morphogenetic Proteins and Transforming Growth Factor-βs in the Pathogenesis of OPLL and OLF

      • Hideki Yoshikawa

      Pages 59-63

   8. Pathology of Spinal Cord Lesions Caused by Ossification of the Posterior Longitudinal Ligament

      • Yoshio Hashizume, Takashi Kameyama, Junichi Mizuno, Hiroshi Nakagawa, Tsutomu Yanagi, Mari Yoshida

      Pages 65-70

   9. Tiptoe Walking (ttw) Mouse

      • Shiro Ikegawa

      Pages 71-75

   10. Study of Ligament Ossification and Abnormal Glucose Tolerance in the Zucker Fatty Rat

       • Kengo Yamamoto, Kosuke Kubo

       Pages 77-91

   11. Experimental Murine Model of Ossification of Spinal Ligaments Induced by Bone Morphogenetic Protein-2

       • Kazuto Hoshi

       Pages 93-100

   12. Spinal Cord Lesions in Spinal Hyperostotic Mouse (twy/twy) Simulating Ossification of the Posterior Longitudinal Ligament of the Cervical Spine

       • Hisatoshi Baba, Kenzo Uchida, Hideaki Nakajima, Yasuo Kokubo, Ryuichiro Sato, Takafumi Yayama et al.

       Pages 101-107

5. Diagnosis of OPLL and OYL

   1. Front Matter

      Pages 109-109

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Ossification of the posterior longitudinal ligament (OPLL) is a hyperostotic condition of the spine with severe neurological deficits. In 1975 the Investigation Committee for OPLL, under the auspices of the Japanese Ministry of Health and Welfare, established diagnostic criteria for the condition, and with growing awareness of OPLL among Japanese researchers and spinal surgeons, the number of patients diagnosed with the condition in Japan has increased in recent years. As knowledge of OPLL has spread, there has also been an increase in the number of reported cases of the condition in other parts of the world: Asia, the United States, and Europe. Until now, however, little has been published on the subject in English; thus the appearance of this present volume is most timely. It brings together information on all aspects of OPLL - epidemiology, etiology, diagnosis, and treatment - with contributions by Japanese researchers and surgeons, including members of the Ministry of Health and Welfare Investigation Committee, and by American surgeons with expertise in the field. This collection of reports on OPLL, amply augmented with illustrations, will be of special interest to orthopedic surgeons and neurosurgeons, and to neurologists, rheumatologists, neuroradiologists, and pathologists.

• Myelopathy
• bone
• clinical trial
• decompression
• imaging
• ossfication of the posterior logitudinal ligament
• pathology
• sonography
• spinal cord
• spine
• surgery

• National Hospital Organization, Osaka-Minami Medical Center, Osaka, Japan

  Kazuo Yonenobu

• Department of Orthopaedic Surgery Faculty of Medicine, The University of Tokyo, Tokyo, Japan

  Kozo Nakamura

• Department of Orthopedic Surgery School of Medicine, Keio University 35 Shinanomachi, Tokyo, Japan

  Yoshiaki Toyama

Policies and ethics