Sinus node inhibitors

A new concept in angina pectoris

Editors: Hjalmarsson, A., Remme, W.J. (Eds.)

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About this book

Although surgical and catheter-based revascularization techniques have substan­ tially improved today's therapeutic potential in ischemic heart disease, in the majority of patients treatment will be conservative for a number of reasons, the cost-effectiveness of non-pharmacological approaches being of major importance. During the last two decades, drug development for ischemic heart disease has been impressive and many new compounds have been added to our therapeutic armamentarium. Nevertheless, where mode of action is concerned, it is interesting to note that, despite all these efforts, we are still confined to three categories of drugs. Antithrombotics and platelet-active agents aside, these concern nitrates, betablocking drugs and calcium antagonists, agents which reduce ischemia by diminishing cardiac work or wall stress,. thereby affecting myocardial oxygen demand and/or by improving coronary blood flow. Alone or in combination, these agents have proved to be efficacious in the treatment of angina pectoris or other symptoms of ischemic heart disease in a number of patients, but certainly not in all. Moreover, as side-effects are often a problem with current antianginal compounds, the physician may find himself restricted in his therapeutic capabilities and in need of new and, preferably, alternative forms of pharmacological treatment.

Table of contents (6 chapters)

  • Reduction of heart rate — Really a new concept in treating angina pectoris?

    Hjalmarson, Åke, MD

    Pages 1-8

  • ULFS 49 CL, a prototype of a novel pharmacological concept

    Lillie, Christian

    Pages 9-19

  • Sinus node inhibitors for reducing exercise-induced myocardial ischemia: Evidence from experimental animal studies

    Guth, Brian D., Ph. D.

    Pages 21-35

  • Electrophysiological effects of ULFS 49 CL

    Seidl, Dr. K. (et al.)

    Pages 37-44

  • Antiischemic, antianginal, and hemodynamic effects of ULFS 49 CL (a new heart-rate-reducing agent) in patients with angiographically proven CAD

    Pitschner, Dr. H. F. (et al.)

    Pages 45-53

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-72458-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.00
price for USA in USD
  • ISBN 978-3-7985-0861-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Sinus node inhibitors
Book Subtitle
A new concept in angina pectoris
Editors
  • A. Hjalmarsson
  • W.J. Remme
Copyright
1991
Publisher
Steinkopff-Verlag Heidelberg
Copyright Holder
Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt
eBook ISBN
978-3-642-72458-9
DOI
10.1007/978-3-642-72458-9
Softcover ISBN
978-3-7985-0861-3
Edition Number
1
Number of Pages
VIII, 64
Number of Illustrations and Tables
3 b/w illustrations
Topics