Progress in Inflammation Research

Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

Editors: Vukicevic, Slobodan, Sampath, Kuber T. (Eds.)

Free Preview
  • Written by experts in the field
  • Completes the series of PIR-volumes on BMPs by S. Vukicevic/K.T. Sampath with most recent data (Bone Morphogenetic Proteins - Regeneration of Bone and Beyond / 2004; and Bone Morphogenetic Proteins - From Laboratory to Clinical Practice / 2002)
see more benefits

Buy this book

eBook $209.00
price for USA in USD (gross)
  • ISBN 978-3-7643-8552-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $269.00
price for USA in USD
  • ISBN 978-3-7643-8551-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs.

In this volume, we summarize the advances made on the local and systemic use of BMPs including chapters covering the regulation of BMP-signalling pathways, biological actions of BMPs in bone, cartilage and teeth, as well as clinical applications and potential systemic use of BMPs for tissues beyond bone.

This volume is of interest to researchers from immunology, cell biology, biochemistry, and clinicians from orthopedics and dentistry, as well as to research managers from biotech and pharmaceutical companies.

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Introduction

    Pages 1-5

    Vukicevic, Slobodan (et al.)

  • Development of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results

    Pages 7-23

    McKay, William F. (et al.)

  • Use of recombinant human BMP-2 in orthopedic trauma

    Pages 25-42

    Suk, Michael

  • The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects

    Pages 43-70

    Spagnoli, Daniel B.

  • Clinical outcomes using rhBMP-2 in spinal fusion applications

    Pages 71-80

    Kenneth Burkus, J.

Buy this book

eBook $209.00
price for USA in USD (gross)
  • ISBN 978-3-7643-8552-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $269.00
price for USA in USD
  • ISBN 978-3-7643-8551-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Bone Morphogenetic Proteins: From Local to Systemic Therapeutics
Editors
  • Slobodan Vukicevic
  • Kuber T. Sampath
Series Title
Progress in Inflammation Research
Copyright
2008
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Basel
eBook ISBN
978-3-7643-8552-1
DOI
10.1007/978-3-7643-8552-1
Hardcover ISBN
978-3-7643-8551-4
Series ISSN
0379-0363
Edition Number
1
Number of Pages
XI, 343
Number of Illustrations
79 b/w illustrations, 36 illustrations in colour
Topics