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Systems Biological Approaches in Infectious Diseases

  • Book
  • © 2007

Overview

Editors:
  1. Helena I. Boshoff

    1. Tuberculosis Research Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, USA

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  2. Clifton E. Barry

    1. Tuberculosis Research Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Gives an overview of computation and modelling of "omics" data
  • Special emphasis on identification of novel drug targets
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Drug Research (PDR, volume 64)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-ix
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  2. Systems biology and its impact on anti-infective drug development

    • Michael P. Stumpf, Brian D. Robertson, Ken Duncan, Douglas B. Young
    Pages 1-20

  3. Applications of transcriptional profiling in antibiotics discovery and development

    • Hans Peter Fischer, Christoph Freiberg
    Pages 21-47

  4. Chemical genetics: An evolving toolbox for target identification and lead optimization

    • Helena I. Boshoff, Cynthia S. Dowd
    Pages 49-77

  5. Proteomic profiling of cellular stresses in Bacillus subtilis reveals cellular networks and assists in elucidating antibiotic mechanisms of action

    • Julia E. Bandow, Michael Hecker
    Pages 79-101

  6. Elucidating the mode-of-action of compounds from metabolite profiling studies

    • Jesper Højer-Pedersen, Jørn Smedsgaard, Jens Nielsen
    Pages 103-129

  7. A subsystems-based approach to the identification of drug targets in bacterial pathogens

    • Andrei L. Osterman, Tadhg P. Begley
    Pages 131-170

  8. Metabolic control analysis to identify optimal drug targets

    • Jorrit J. Hornberg, Frank J. Bruggeman, Barbara M. Bakker, Hans V. Westerhoff
    Pages 171-189

  9. The protein network as a tool for finding novel drug targets

    • Michael Strong, David Eisenberg
    Pages 191-215

  10. Toxicogenomics applied to predictive and exploratory toxicology for the safety assessment of new chemical entities: a long road with deep potholes

    • François Pognan
    Pages 217-238

  11. Biological robustness in complex host-pathogen systems

    • Hiroaki Kitano
    Pages 239-263

  12. Toward whole cell modeling and simulation: Comprehensive functional genomics through the constraint-based approach

    • Andrew R. Joyce, Bernhard Ø. Palsson
    Pages 265-309

  13. Genomics of host-pathogen interactions

    • Dirk Schnappinger
    Pages 311-343

  14. Back Matter

    Pages 345-349
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Keywords

About this book

Systems biology is an emerging discipline that studies the underlying network structure and the dynamics of metabolism, cells or whole organisms. It aims to investigate all interacting components simultaneously and requires data from high throughput techniques. These data from the "omic" sciences are computed and used to build in silico models of biological systems that ultimately will prove to be an invaluable tool in drug development.

This book brings together the various fields of functional genomics and systems biology that provide information on metabolic function with a special emphasis on the identification of drug targets. It includes practical examples from the various "omic" sciences as well as theoretical examples of how integrated knowledge of these sciences can be applied to drug discovery. It is of interest to researchers in the pharmaceutical drug discovery environment, as well as those in the academic field with an interest in the functional application of the "omic" sciences.

Editors and Affiliations

  • Tuberculosis Research Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, USA

    Helena I. Boshoff, Clifton E. Barry

Bibliographic Information

  • Book Title: Systems Biological Approaches in Infectious Diseases

  • Editors: Helena I. Boshoff, Clifton E. Barry

  • Series Title: Progress in Drug Research

  • DOI: https://doi.org/10.1007/978-3-7643-7567-6

  • Publisher: Birkhäuser Basel

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Birkhäuser Basel 2007

  • Hardcover ISBN: 978-3-7643-7566-9Published: 20 November 2006

  • eBook ISBN: 978-3-7643-7567-6Published: 15 January 2007

  • Series ISSN: 0071-786X

  • Series E-ISSN: 2297-4555

  • Edition Number: 1

  • Number of Pages: IX, 350

  • Topics: Molecular Medicine

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