Milestones in Drug Therapy

Erythropoietins and Erythropoiesis

Molecular, Cellular, Preclinical, and Clinical Biology

Editors: Molineux, Graham, Foote, Mary A., Elliott, Steven (Eds.)

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About this book

Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Although much has been learned and published, new, exciting data are becoming ava- able on almost a daily basis. Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology compiles both pertinent historical and very recent research on this molecule and its clinical utility. The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified,cloned,and expressed,the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Erythropoiesis: an overview

    Israels, Lyonel G. (et al.)

    Pages 3-14

  • Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin

    Foote, MaryAnn

    Pages 15-23

  • Structural basis for the signal transduction of erythropoietin

    Osslund, Timothy (et al.)

    Pages 25-34

  • Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues

    Dame, Christof

    Pages 35-64

  • Erythropoietin receptor signaling processes

    Ghaffari, Saghi (et al.)

    Pages 65-85

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-7643-7543-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.00
price for USA in USD
  • ISBN 978-3-7643-7542-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Erythropoietins and Erythropoiesis
Book Subtitle
Molecular, Cellular, Preclinical, and Clinical Biology
Editors
  • Graham Molineux
  • Mary A. Foote
  • Steven Elliott
Series Title
Milestones in Drug Therapy
Copyright
2006
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Basel
eBook ISBN
978-3-7643-7543-0
DOI
10.1007/3-7643-7543-4
Softcover ISBN
978-3-7643-7542-3
Series ISSN
2296-6056
Edition Number
1
Number of Pages
XII, 270
Topics