Progress in Inflammation Research

Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation

Editors: Malmberg, Annika B., Bley, Keith R. (Eds.)

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About this book

Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.

Table of contents (12 chapters)

Table of contents (12 chapters)
  • Hot peppers, pain and analgesics

    Szolcsányi, János

    Pages 3-22

  • Structural determinants of TRPV1 functionality

    Tominaga, Makoto

    Pages 25-37

  • TRPV1 distribution and regulation

    Winter, Janet

    Pages 39-51

  • Insights into TRPV1 pharmacology provided by non-capsaicin ligands

    Blumberg, Peter M. (et al.)

    Pages 55-69

  • Endocannabinoids and vanilloid TRPV1 receptors

    Ross, Ruth A.

    Pages 71-93

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-3-7643-7379-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-7643-7080-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation
Editors
  • Annika B. Malmberg
  • Keith R. Bley
Series Title
Progress in Inflammation Research
Copyright
2005
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Basel
eBook ISBN
978-3-7643-7379-5
DOI
10.1007/3-7643-7379-2
Hardcover ISBN
978-3-7643-7080-0
Series ISSN
0379-0363
Edition Number
1
Number of Pages
XII, 249
Topics